New immunotherapy cocktail aims to fight untreatable liver cancer

NCT ID NCT05904886

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing whether adding tiragolumab to the standard combination of atezolizumab and bevacizumab helps people with advanced liver cancer that cannot be surgically removed. About 687 participants will receive either the three-drug combo or the two-drug combo plus a placebo. The study measures how long the cancer stays under control and overall survival, but the tiragolumab arm was recommended to stop early, so results should be interpreted cautiously.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tiragolumab (an immunotherapy drug) combined with atezolizumab and bevacizumab
What this could lead to: If successful, this combination could offer a new first-line treatment option for people with advanced liver cancer, potentially improving how long they live and delaying cancer growth.
What could go wrong: This is an early-stage analysis of a large trial; the tiragolumab arm was recommended to stop early due to a sponsor memo, raising questions about benefit. Side effects from immunotherapy can be serious, and the added benefit of tiragolumab is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA

Contacts and locations

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Locations

?zmir Medical Point

Kar?iyaka, 35575, Turkey (Türkiye)
A.O. S. Orsola Malpighi

Bologna, Emilia-Romagna, 40138, Italy
A.O.U. Policlinico Paolo Giaccone

Palermo, Sicily, 90127, Italy
A.O.U.I. Verona-Ospedale Policlinico G.B. Rossi Borgo Roma

Verona, Veneto, 37134, Italy
APHP - Hopital Saint Antoine

Paris, 75571, France
AZ Delta (Campus Rumbeke)

Roeselare, 8800, Belgium
Adana Baskent University Medical Faculty

Adana, 01220, Turkey (Türkiye)
Anhui Provincial Hospital

Hefei, 230001, China
Ankara Bilkent City Hospital

Ankara, 06490, Turkey (Türkiye)
Asan Medical Center

Seoul, 05505, South Korea
Auckland City Hospital

Auckland, 1023, New Zealand
Az. Osp. G. Panico

Tricase, Apulia, Italy
Az. Osp. Uni Ria San Martino

Genoa, Liguria, 16132, Italy
Baoji Central Hospital

Baoji, 721008, China
Beijing Cancer Hospital

Beijing, 100142, China
CEDOES - Diagnóstico e Pesquisa

Vitória, Espírito Santo, 29055-450, Brazil
CHA Bundang Medical Center

Gyeonggi-do, 13496, South Korea
CHRU de Lille - Hopital Claude Huriez

Lille, 59037, France
CHU CAEN - Hôpital de la Côte de Nacre

Caen, 14033, France
Cancer & Hematology Centers of Western Michigan

Grand Rapids, Michigan, 49503, United States
Centre Hospitalier Valence

Valence, 26953, France
Centre National d'Oncologie Médicale et de Radiothérapie Alassane Ouattara (CNRAO)

Abidjan, Côte d’Ivoire
Centro Medico Nacional Siglo Xxi - Imss

Mexico City, Mexico CITY (federal District), 06720, Mexico
Centro de Investigacion Clinica de Oaxaca

Oaxaca City, Oaxaca, 68020, Mexico
Chang Gung Medical Foundation - Linkou

Taoyuan, 333, Taiwan
Charlotte Maxeke Johannesburg Academic Hospital

Johannesburg, 2193, South Africa
Chi-Mei Medical Centre

Tainan, 710, Taiwan
Chiba University Hospital

Chiba, 260-8677, Japan
China Medical University Hospital

Taichung, 404, Taiwan
Chonnam National University Hwasun Hospital

Jeollanam-do, 58128, South Korea
Christchurch Hospital

Christchurch, 8011, New Zealand
Chulalongkorn Hospital

Bangkok, 10330, Thailand
City of Hope Cancer Center

Duarte, California, 91010, United States
Clinica Universitaria de Navarra

Pamplona/iruña, Navarre, 31008, Spain
Clinica Universitaria de Navarra de Madrid;Servicio de Hepatologia

Madrid, 28027, Spain
Clinicas Oncologicas Integradas - COI

Rio de Janeiro, 22290-160, Brazil
Cliniques Universitaires St-Luc

Brussels, 1200, Belgium
Columbia University

New York, New York, 10032-3725, United States
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico

Jaén, 23007, Spain
Ehime Prefectural Central Hospital

Ehime, 790-0024, Japan
First Affiliated Hospital of Medical College of Xi'an Jiaotong University

Xi'an, 710061, China
Florida Cancer Specialist, North Region

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists - Fort Myers (Broadway)

Fort Myers, Florida, 33901, United States
Fondation Hopital Saint Joseph

Marseille, 13285, France
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Rome, Lazio, 00168, Italy
Fujita Health University Hospital

Aichi, 470-1192, Japan
Gazi Uni Medical Faculty Hospital

Ankara, 06500, Turkey (Türkiye)
Genesis Cancer Center

Hot Springs, Arkansas, 71913, United States
Hammersmith Hospital

London, W12 0HS, United Kingdom
Harbin Medical University Cancer Hospital

Harbin, 150081, China
Hartford Healthcare Cancer Institute at Hartford Hospital

Hartford, Connecticut, 06106, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hiroshima University Hospital

Hiroshima, 734-8551, Japan
Hokkaido University Hospital

Hokkaido, 060-8648, Japan
Hopital Dupuytren

Limoges, 87042, France
Hopital Hotel Dieu Et Hme

Nantes, 44093, France
Hopital Paul Brousse

Villejuif, 94804, France
Hopital Robert Debre

Reims, 51092, France
Hopitaux de Brabois - Gastro-Entereologie

Vandœuvre-lès-Nancy, 54511, France
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Clinico de Valencia

Valencia, 46010, Spain
Hospital Duran i Reynals

Barcelona, 08907, Spain
Hospital General Universitario Gregorio Marañon

Madrid, 28007, Spain
Hospital Sao Lucas - PUCRS

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Puerta de Hierro

Madrid, 28222, Spain
Hospital de Cancer de Barretos

Barretos, São Paulo, 14784-400, Brazil
Hospital de Navarra

Navarra, Navarre, 31008, Spain
Hospital do Cancer de Pernambuco - HCP

Recife, Pernambuco, 50040-000, Brazil
Hunan Cancer Hospital

Changsha, 410013, China
ID Clinic

Mysłowice, 41-400, Poland
IRCCS Istituto Clinico Humanitas

Rozzano, Lombardy, 20089, Italy
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Instituto Nacional de Ciencias Médicas Y de Nutricion Salvador Zubirán

Mexico City, Mexico CITY (federal District), 14000, Mexico
Instituto do Cancer do Estado de Sao Paulo - ICESP

São Paulo, São Paulo, 01246-000, Brazil
Iwate Medical University Hospital

Numakunai, 028-3695, Japan
James J Peters VA Hospital / Mental Illness Research Education and Clinic Center

The Bronx, New York, 10468, United States
Japanese Red Cross Musashino Hospital

Tokyo, 180-8610, Japan
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Jichi Medical University Hospital

Tochigi, 329-0498, Japan
Jos University Teaching Hospital

Jos, 930232, Nigeria
Juravinski Hospital

Hamilton, Ontario, L8V 1C3, Canada
KBTH

Accra, 0000, Ghana
Kanagawa Cancer Center

Kanagawa, 241-8515, Japan
Kanazawa University Hospital

Ishikawa, 920-8641, Japan
Kelsey Seybold Clnic

Houston, Texas, 77005, United States
Khon Kaen Uni

Khon Kaen, 40002, Thailand
Kindai University Hospital

Osaka, 589-8511, Japan
Kitasato University Hospital

Kanagawa, 252-0375, Japan
Klinikum Esslingen

Esslingen am Neckar, 73730, Germany
Kurume University Hospital

Fukuoka, 830-0011, Japan
Kyoto University Hospital

Kyoto, 606-8507, Japan
Lagos University Teaching Hospital Lagos (LUTH), Lagos State

Lagos, Nigeria
Limpopo Cancer Research Institute

Polokwane, 0700, South Africa
Lishui Central Hospital

Lishui, 323000, China
Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, 50200, Thailand
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
McGill University Health Centre - Glen Site

Montreal, Quebec, H4A 3J1, Canada
MedStar Washington Hosp Center

Washington D.C., District of Columbia, 20010, United States
Mengchao Hepatobiliary Hospital Of Fujian Medical University

Fuzhou, 350025, China
Mercy Medical Center

Baltimore, Maryland, 21202, United States
Miami VA Healthcare System

Miami, Florida, 33125, United States
Minnesota Oncology Hematology Woodbury

Woodbury, Minnesota, 55125, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
NIO im Marii Sklodowskiej-Curie

Warsaw, 02-034, Poland
NYU Langone

New York, New York, 10016, United States
Nanfang Hospital, Southern Medical University

Guangzhou, 510515, China
National Cancer Center

Goyang-si, 10408, South Korea
National Cancer Center Hospital East

Chiba, 277-8577, Japan
National Cancer Centre

Singapore, 168583, Singapore
National Cheng Kung University Hospital

Tainan, 00704, Taiwan
National Taiwan Uni Hospital

Taipei, 100, Taiwan
North Texas VA Medical Center

Dallas, Texas, 75216, United States
Norton Cancer Institute - Audubon

Louisville, Kentucky, 40217, United States
Ochsner Cancer Inst.

New Orleans, Louisiana, 70121, United States
OncoMed

Mexico City, Mexico CITY (federal District), 03100, Mexico
Oncoclínicas do Brasil - BELO HORIZONTE

Belo Horizonte, Minas Gerais, 30170-080, Brazil
PanOncology Trials

San Juan, 00935, Puerto Rico
Peoples Hospital of Hunan Province

Changsha, 410007, China
Polyclinique Internationale Sainte Anne- Marie (PISAM)

Abidjan, BP 1463 Abidjan, Côte d’Ivoire
Prince of Wales Hosp

Shatin, Hong Kong
Queen Mary Hospital

Hong Kong, Hong Kong
Ramathibodi Hospital

Bangkok, 10400, Thailand
Renji Hospital Shanghai Jiaotong University School of Medicine

Shanghai, 200127, China
Royal Free Hospital

London, NW3 2QG, United Kingdom
Samsung Medical Center

Seoul, 06351, South Korea
Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Sapporo Kosei General Hospital

Hokkaido, 060-0033, Japan
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 003-722, South Korea
Shengjing Hospital of China Medical University

Shenyang, 110004, China
Stanford Cancer Center

Palo Alto, California, 94304, United States
Sun yat-sen University Cancer Center

Guangzhou, China
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Sweden Ghana Medical Center

Accra, Ghana
Swedish Cancer Inst.

Seattle, Washington, 98104, United States
The First Affiliated Hospital of College of Medicine, Zhejiang University

Hangzhou, 310003, China
The First Hospital of Jilin University

Changchun, 130021, China
The Second Affiliated Hospital of Anhui Medical University

Hefei, 230601, China
The University of Osaka Hospital

Osaka, 565-0871, Japan
Thomas Jefferson Uni

Philadelphia, Pennsylvania, 19107, United States
Tianjin Cancer Hospital

Tianjin, 300060, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, 430030, China
Toranomon Branch Hospital

Kanagawa, 213-8587, Japan
Toranomon Hospital

Tokyo, 105-8470, Japan
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi

Edirne, 22030, Turkey (Türkiye)
UCLA Cancer Center

Santa Monica, California, 90404, United States
UCSF Fresno at Community Cancer Institute

Clovis, California, 93611, United States
UZ Antwerpen

Edegem, 2650, Belgium
Uganda Cancer Institute

Kampala, Uganda
Ulsan University Hosiptal

Ulsan, 44033, South Korea
Uniklinik Mainz

Mainz, 55131, Germany
Univ of Wisconsin-Madison

Madison, Wisconsin, 53792, United States
University Hospital Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan
University of California San Diego Moores Cancer Center

La Jolla, California, 92037, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Nairobi - Institute of Tropical and Infectious Diseases

Nairobi, Kenya
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27514, United States
University of Southern California

Los Angeles, California, 90033, United States
Universität Tübingen

Tübingen, 72076, Germany
Universitätsklinikum Magdeburg Klinik für Gastroenterologie und Hepatologie

Magdeburg, 39120, Germany
Va Palo Alto Health Care System

Palo Alto, California, 94304, United States
Virginia Mason Medical Center

Seattle, Washington, 98101, United States
Washington Uni School of Medicine

St Louis, Missouri, 63110, United States
Wellington Hospital

Wellington, 6021, New Zealand
West China Hospital - Sichuan University

Chengdu, 610047, China
Western General Hospital

Edinburgh, EH4 2XU, United Kingdom
Xi'an Inernational Medical Center Hospital

Xi'an, 710119, China
Zhejiang Provincial People?s Hospital

Hangzhou, 310014, China
Zhongshan Hospital Fudan Unvierstiy

Shanghai, 200032, China

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