Virus plus immunotherapy shows promise against resistant ovarian cancer

NCT ID NCT05271318

First seen Nov 03, 2025 · Last updated May 15, 2026 · Updated 27 times

Summary

This early-stage trial tests a specially designed virus (TILT-123) that targets and kills cancer cells while also boosting the immune system. It is given together with the immunotherapy drug pembrolizumab (Keytruda) and sometimes chemotherapy, to women with ovarian cancer that no longer responds to platinum-based treatments. The main goal is to check safety and find the best dose in 29 participants.

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Contacts and locations

Locations

  • Docrates Cancer Center

    Helsinki, 00180, Finland

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Northwell Heatlh/Lenox Hill Hospital

    New York, New York, 10075, United States

Conditions

Explore the condition pages connected to this study.