Supercharging your own immune cells to fight melanoma

NCT ID NCT02360579

Completed Disease control Sponsor: Iovance Biotherapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jan 08, 2026 · Last updated May 14, 2026 · Updated 15 times

Summary

This study tested a new treatment for people with advanced melanoma that has spread or cannot be removed. The treatment uses a patient's own immune cells, called tumor-infiltrating lymphocytes (TILs), which are grown in a lab and then given back to the patient. The goal was to see if this personalized cell therapy could shrink tumors in patients who had already tried other treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Addenbrooke's Hospital

Cambridge, CB2 0QQ, United Kingdom
Atlantic Health System

Morristown, New Jersey, 07960, United States
Beatson West of Scotland Cancer Centre

Glasgow, Scotland, G12 0YN, United Kingdom
California Pacific Medical Center

San Francisco, California, 94115, United States
Centre Hospitalier Lyon Sud

Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
Centre Hospitalier Universitaire Vaudois Lausanne - Centre Pluridisciplinaire d'Oncologie

Lausanne, Switzerland
Centre Léon Bérard

Lyon, Auvergne-Rhône-Alpes, 69008, France
Centro di Riferimento Oncologico di Aviano

Aviano, Pordenone, 33081, Italy
Clínica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Consorci Hospital General Universitari de València

Valencia, Spain
Gustave Roussy Cancer Campus

Villejuif, Île-de-France Region, 94805, France
HM Centro Integral Oncológico Clara Campal

Madrid, 28050, Spain
Hospital 12 de Octubre

Madrid, 28041, Spain
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hospital General Universitario Gregorio Marañon

Madrid, 28007, Spain
Hospital Universitari Vall d'Hebrón

Barcelona, 08035, Spain
Hospital Universitario Quirónsalud Madrid

Madrid, 28233, Spain
Hôpital Dupuytren

Limoges, Limousin, 87042, France
Indiana University

Indianapolis, Indiana, 46202-5116, United States
Inselspital

Bern, 3010, Switzerland
Institut Català d'Oncologia

Barcelona, 08907, Spain
Istituto Europeo di Oncologia

Milan, 20141, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale

Naples, 80131, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Meldola, Forli-cesena, 47014, Italy
Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia

Candiolo, Torino, 10060, Italy
James Graham Brown Cancer Center

Louisville, Kentucky, 40202, United States
Klinikum Rechts der Isar der Technischen Universität München

München, Bavaria, 81675, Germany
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Mount Sinai Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States
New York University Langone Medical Center

New York, New York, 10016, United States
Providence Cancer Center Oncology and Hematology Care Clinic

Portland, Oregon, 97213, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Royal Marsden NHS Trust

London, England, SW3 6JJ, United Kingdom
Rutgers University

New Brunswick, New Jersey, United States
Sarah Cannon Research Institute London

London, W1G 6AD, United Kingdom
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Szegedi Tudomanyegyetem Szent-Györgyi Albert Klinikai Központ

Szeged, Csongrád megye, 6720, Hungary
The Angeles Clinic and Research Institute

Los Angeles, California, 90048, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19701, United States
Universitaetsklinikum Heidelberg

Heidelberg, Baden-Wurttemberg, 69120, Germany
Universitaetsklinikum Tuebingen (UKT) - Suedwestdeutschen Tumorzentrum - Zentrum für Neuroonkologie

Tübingen, Baden-Wurttemberg, 72076, Germany
University of California Los Angeles - David Geffen School of Medicine - Westwood Rheumatology

Los Angeles, California, 90095, United States
University of California San Diego Moores Cancer Center

La Jolla, California, 92093, United States
University of Colorado Cancer Center

Aurora, Colorado, 80049, United States
University of Florida Health Cancer Center

Orlando, Florida, 32806, United States
University of Miami

Miami, Florida, 33136, United States
University of Minnesota, Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
University of Pittsburgh Medical Center - Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of South Florida H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, 33612, United States
Universitätsklinikum Carl Gustav Carus

Dresden, Saxony, Germany
Universitätsklinikum Erlangen

Erlangen, Bavaria, 91052, Germany
Universitätsklinikum Halle

Halle, Saxony-Anhalt, 06120, Germany
Universitätsklinikum Leipzig

Leipzig, Saxony, 4103, Germany
Universitätsklinikum Schleswig-Holstein - Campus Lübeck

Lübeck, Schleswig-Holstein, 23538, Germany
Universitätsklinikum Würzburg

Würzburg, 97080, Germany
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Yale Cancer Center

New Haven, Connecticut, 06510, United States

Conditions

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METASTATIC MELANOMA