Head-to-Head trial seeks best drug combo for tough thyroid cancer

NCT ID NCT06475989

Recruiting now Disease control Sponsor: ECOG-ACRIN Cancer Research Group Source: ClinicalTrials.gov ↗

Summary

This study aims to find out which of two drug treatments works better for people with an advanced form of thyroid cancer that has a specific genetic change (BRAF V600E) and has stopped responding to standard therapies. Researchers will compare a two-drug combination (dabrafenib and trametinib) against a single drug (cabozantinib) in about 264 participants. The main goal is to see which treatment better controls cancer growth and extends the time patients live without their disease getting worse.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States

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Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Billings Clinic-Cody
RECRUITING

Cody, Wyoming, 82414, United States

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Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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CARTI Cancer Center
RECRUITING

Little Rock, Arkansas, 72205, United States

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Cambridge Medical Center
RECRUITING

Cambridge, Minnesota, 55008, United States

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Cancer Center of Western Wisconsin
RECRUITING

New Richmond, Wisconsin, 54017, United States

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Central Care Cancer Center - Bolivar
RECRUITING

Bolivar, Missouri, 65613, United States

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Central Care Cancer Center - Garden City
RECRUITING

Garden City, Kansas, 67846, United States

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Central Care Cancer Center - Great Bend
RECRUITING

Great Bend, Kansas, 67530, United States

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Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

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Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

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Cox Cancer Center Branson
RECRUITING

Branson, Missouri, 65616, United States

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CoxHealth South Hospital
RECRUITING

Springfield, Missouri, 65807, United States

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Delbert Day Cancer Institute at PCRMC
RECRUITING

Rolla, Missouri, 65401, United States

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Fairview Clinics and Surgery Center Maple Grove
RECRUITING

Maple Grove, Minnesota, 55369, United States

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Fairview Lakes Medical Center
RECRUITING

Wyoming, Minnesota, 55092, United States

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Fairview Northland Medical Center
RECRUITING

Princeton, Minnesota, 55371, United States

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Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States

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Freeman Health System
RECRUITING

Joplin, Missouri, 64804, United States

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Good Samaritan Regional Health Center
RECRUITING

Mount Vernon, Illinois, 62864, United States

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Great Falls Clinic
RECRUITING

Great Falls, Montana, 59405, United States

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Health Partners Inc
RECRUITING

Minneapolis, Minnesota, 55454, United States

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Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States

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Hennepin County Medical Center
RECRUITING

Minneapolis, Minnesota, 55415, United States

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Idaho Urologic Institute-Meridian
RECRUITING

Meridian, Idaho, 83642, United States

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Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

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Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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Lake Regional Hospital
RECRUITING

Osage Beach, Missouri, 65065, United States

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Lakeview Hospital
RECRUITING

Stillwater, Minnesota, 55082, United States

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Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

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Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

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Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

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Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

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Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

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Mercy Clinic-Rolla-Cancer and Hematology
RECRUITING

Rolla, Missouri, 65401, United States

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Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States

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Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States

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Mercy Hospital Fort Smith
RECRUITING

Fort Smith, Arkansas, 72903, United States

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Mercy Hospital Joplin
RECRUITING

Joplin, Missouri, 64804, United States

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Mercy Hospital Oklahoma City
RECRUITING

Oklahoma City, Oklahoma, 73120, United States

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Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States

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Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States

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Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States

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Mercy Hospital Washington
RECRUITING

Washington, Missouri, 63090, United States

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Minnesota Oncology - Burnsville
RECRUITING

Burnsville, Minnesota, 55337, United States

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Minnesota Oncology Hematology PA-Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States

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Minnesota Oncology Hematology PA-Woodbury
RECRUITING

Woodbury, Minnesota, 55125, United States

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Monticello Cancer Center
RECRUITING

Monticello, Minnesota, 55362, United States

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New Ulm Medical Center
RECRUITING

New Ulm, Minnesota, 56073, United States

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North Memorial Medical Health Center
RECRUITING

Robbinsdale, Minnesota, 55422, United States

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Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States

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Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States

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Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States

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Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States

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Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States

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Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

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Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

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Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

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OSF Saint Anthony's Health Center
RECRUITING

Alton, Illinois, 62002, United States

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Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States

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Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States

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Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States

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Rice Memorial Hospital
RECRUITING

Willmar, Minnesota, 56201, United States

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Ridgeview Medical Center
RECRUITING

Waconia, Minnesota, 55387, United States

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Saint Alphonsus Cancer Care Center-Baker City
RECRUITING

Baker City, Oregon, 97814, United States

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Saint Alphonsus Cancer Care Center-Boise
RECRUITING

Boise, Idaho, 83706, United States

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Saint Alphonsus Cancer Care Center-Caldwell
RECRUITING

Caldwell, Idaho, 83605, United States

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Saint Alphonsus Cancer Care Center-Nampa
RECRUITING

Nampa, Idaho, 83687, United States

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Saint Alphonsus Cancer Care Center-Ontario
RECRUITING

Ontario, Oregon, 97914, United States

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Saint Francis Regional Medical Center
RECRUITING

Shakopee, Minnesota, 55379, United States

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Saint John's Hospital - Healtheast
RECRUITING

Maplewood, Minnesota, 55109, United States

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Saint Louis Cancer and Breast Institute-Ballwin
RECRUITING

Ballwin, Missouri, 63011, United States

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Saint Louis Cancer and Breast Institute-South City
RECRUITING

St Louis, Missouri, 63109, United States

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Saint Mary's Hospital
RECRUITING

Centralia, Illinois, 62801, United States

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Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

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Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

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Sanford Cancer Center Worthington
RECRUITING

Worthington, Minnesota, 56187, United States

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Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

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Sanford Medical Center Fargo
RECRUITING

Fargo, North Dakota, 58104, United States

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Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford South University Medical Center
RECRUITING

Fargo, North Dakota, 58103, United States

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Sanford Thief River Falls Medical Center
RECRUITING

Thief River Falls, Minnesota, 56701, United States

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Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

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Smilow Cancer Center/Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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Smilow Cancer Hospital Care Center - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States

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Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States

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Smilow Cancer Hospital Care Center - Westerly
RECRUITING

Westerly, Rhode Island, 02891, United States

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Smilow Cancer Hospital Care Center at Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States

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Smilow Cancer Hospital Care Center at Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States

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Smilow Cancer Hospital Care Center at Long Ridge
RECRUITING

Stamford, Connecticut, 06902, United States

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Smilow Cancer Hospital Care Center at Saint Francis
RECRUITING

Hartford, Connecticut, 06105, United States

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Smilow Cancer Hospital Care Center-Fairfield
RECRUITING

Fairfield, Connecticut, 06824, United States

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Smilow Cancer Hospital Care Center-Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States

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Smilow Cancer Hospital-Derby Care Center
RECRUITING

Derby, Connecticut, 06418, United States

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Smilow Cancer Hospital-Torrington Care Center
RECRUITING

Torrington, Connecticut, 06790, United States

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Smilow Cancer Hospital-Waterbury Care Center
RECRUITING

Waterbury, Connecticut, 06708, United States

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Southeast Cancer Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States

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Southpointe-Sanford Medical Center Fargo
RECRUITING

Fargo, North Dakota, 58103, United States

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UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

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United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States

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University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States

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University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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Walter Knox Memorial Hospital
SUSPENDED

Emmett, Idaho, 83617, United States
Welch Cancer Center
RECRUITING

Sheridan, Wyoming, 82801, United States

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Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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Yale-New Haven Hospital North Haven Medical Center
RECRUITING

North Haven, Connecticut, 06473, United States

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Conditions

Explore the condition pages connected to this study.

REFRACTORY DIFFERENTIATED THYROID GLAND CARCINOMA