Could a Telomere-Targeting drug reboot immunotherapy in lung cancer?

NCT ID NCT05208944

Ongoing Disease control Sponsor: Maia Biotechnology Source: ClinicalTrials.gov ↗

First seen Jan 22, 2026 · Last updated May 15, 2026 · Updated 13 times

Summary

This study tests a new drug called THIO, which targets telomeres (parts of chromosomes), followed by the immunotherapy cemiplimab in people with advanced non-small cell lung cancer whose cancer stopped responding to initial immunotherapy. The goal is to see if this sequence can shrink tumors or slow disease progression. About 227 adults with stage 3 or 4 NSCLC are participating.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Bács-Kiskun Megyei Oktatókórház, Onkoradiológiai Központ

Kecskemét, 6000, Hungary
Cancer Research SA

Adelaide, South Australia, 5000, Australia
Central Alabama Research

Birmingham, Alabama, 35209, United States
Centrum Medyczne Mrukmed

Rzeszów, 35-021, Poland
Centrum Medyczne Pratia

Skorzewo, 60-185, Poland
Centrum Onkologii im. prof. F. Lukaszczyka

Bydgoszcz, 85-796, Poland
Centrum Terapii Współczesnej J. M. Jasnorzewska

Lodz, 90-338, Poland
Chang-Gung Memorial Hospital

Kaohsiung City, Niaosong District, 833, Taiwan
Chang-Gung Memorial Hospital - Linko

Taoyuan City, Guishan District, 333, Taiwan
Debreceni Egyetem Klinikai Kozpont, Tudogyogyaszati Klinika

Debrecen, 98, Hungary
Hetenyi Geza Korhaz, Onkologiai Kozpont

Szolnok, u 21, Hungary
Krakowski Szpital Specjalistyczny im. Jana Pawla II Oddzial Onkologii z Pododdzialem Diagnostyki Nowotworow Klatki Piersiowej

Krakow, 31-202, Poland
Liv Hospital Ankara, Medikal Onkoloji Bilim Dalı

Ankara, Turkey (Türkiye)
MC Synexus Sofia EOOD

Sofia, 1784, Bulgaria
MHAT "HEART AND BRAIN" EAD Clinic of Medical Oncology

Pleven, 5800, Bulgaria
MHAT "Serdika" EOOD

Sofia, Bulgaria
Med Polonia Sp z o.o.

Poznan, 60-693, Poland
Mátrai Gyógyintézet

Mátraháza, HRSZ7151, Hungary
NZOZ FORMED 2 Sp. z o.o.

Oświęcim, Oswiecim, 32-600, Poland
National Taiwan University Hospital

Taipei, Zhongzheng District, Taiwan
NeuroMed

Lublin, 20-064, Poland
Orszagos Onkologiai Intezet

Budapest, u. 7-9, Hungary
Országos Korányi Pulmonológiai Intézet

Budapest, u. 1., Hungary
Semmelweis Egyetem Pulmonologiai Klinika

Budapest, 25-29, Hungary
St. Vincent Hospital Melbourne

Fitzroy, Victoria, 3065, Australia
Summit Health

Florham Park, New Jersey, 07932, United States
Sunshine Coast Haematology and Oncology Clinic

Buderim, Queensland, 4556, Australia
Taipei Medical University Hospital

Taipei, Xinyi District, 11031, Taiwan
Taipei Tzu Chi Hospital

New Taipei City, Xindian Dist, 23142, Taiwan
Taipei Veterans General Hospital

Taipei, Beitou District, 11214, Taiwan
Tri-Service General Hospital

Taipei, Neihu District, 114, Taiwan
Tüdőgyógyintézet Törökbálint, Onkológiai Osztályc

Törökbálint, 70. 2045, Hungary
UMHAT "Sofiamed"

Sofia, Bulgaria
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu, Oddzial Chemioterapii Nowotworow

Torun, 87-100, Poland
İstinye Üniversitesi Hastanesi Liv Hospital Bahçeşehir

Istanbul, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.

CARCINOMA, NON-SMALL-CELL LUNG