Could a Telomere-Targeting drug revive immunotherapy in lung cancer?
NCT ID NCT05208944
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests a new drug called THIO, which targets telomeres in cancer cells, followed by the immunotherapy cemiplimab (LIBTAYO) in people with advanced non-small cell lung cancer. The study includes about 227 participants whose cancer has progressed after initial treatment. The goal is to see if this sequence can restore the cancer's response to immunotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
THIO (6-thio-dG) and cemiplimab (LIBTAYO)
What this could lead to
If successful, this combination could offer a new treatment option for people with advanced lung cancer whose disease has stopped responding to standard immunotherapy.
What could go wrong
This is an early-phase, dose-finding trial with a small number of participants. The treatment may not work as hoped, and side effects could be significant.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bács-Kiskun Megyei Oktatókórház, Onkoradiológiai Központ
Kecskemét, 6000, Hungary
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Cancer Research SA
Adelaide, South Australia, 5000, Australia
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Central Alabama Research
Birmingham, Alabama, 35209, United States
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Centrum Medyczne Mrukmed
Rzeszów, 35-021, Poland
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Centrum Medyczne Pratia
Skorzewo, 60-185, Poland
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Centrum Onkologii im. prof. F. Lukaszczyka
Bydgoszcz, 85-796, Poland
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Centrum Terapii Współczesnej J. M. Jasnorzewska
Lodz, 90-338, Poland
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Chang-Gung Memorial Hospital
Kaohsiung City, Niaosong District, 833, Taiwan
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Chang-Gung Memorial Hospital - Linko
Taoyuan City, Guishan District, 333, Taiwan
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Debreceni Egyetem Klinikai Kozpont, Tudogyogyaszati Klinika
Debrecen, 98, Hungary
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Hetenyi Geza Korhaz, Onkologiai Kozpont
Szolnok, u 21, Hungary
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Krakowski Szpital Specjalistyczny im. Jana Pawla II Oddzial Onkologii z Pododdzialem Diagnostyki Nowotworow Klatki Piersiowej
Krakow, 31-202, Poland
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Liv Hospital Ankara, Medikal Onkoloji Bilim Dalı
Ankara, Turkey (Türkiye)
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MC Synexus Sofia EOOD
Sofia, 1784, Bulgaria
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MHAT "HEART AND BRAIN" EAD Clinic of Medical Oncology
Pleven, 5800, Bulgaria
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MHAT "Serdika" EOOD
Sofia, Bulgaria
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Med Polonia Sp z o.o.
Poznan, 60-693, Poland
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Mátrai Gyógyintézet
Mátraháza, HRSZ7151, Hungary
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NZOZ FORMED 2 Sp. z o.o.
Oświęcim, Oswiecim, 32-600, Poland
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National Taiwan University Hospital
Taipei, Zhongzheng District, Taiwan
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NeuroMed
Lublin, 20-064, Poland
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Orszagos Onkologiai Intezet
Budapest, u. 7-9, Hungary
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Országos Korányi Pulmonológiai Intézet
Budapest, u. 1., Hungary
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Semmelweis Egyetem Pulmonologiai Klinika
Budapest, 25-29, Hungary
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St. Vincent Hospital Melbourne
Fitzroy, Victoria, 3065, Australia
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Summit Health
Florham Park, New Jersey, 07932, United States
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Sunshine Coast Haematology and Oncology Clinic
Buderim, Queensland, 4556, Australia
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Taipei Medical University Hospital
Taipei, Xinyi District, 11031, Taiwan
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Taipei Tzu Chi Hospital
New Taipei City, Xindian Dist, 23142, Taiwan
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Taipei Veterans General Hospital
Taipei, Beitou District, 11214, Taiwan
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Tri-Service General Hospital
Taipei, Neihu District, 114, Taiwan
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Tüdőgyógyintézet Törökbálint, Onkológiai Osztályc
Törökbálint, 70. 2045, Hungary
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UMHAT "Sofiamed"
Sofia, Bulgaria
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Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu, Oddzial Chemioterapii Nowotworow
Torun, 87-100, Poland
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İstinye Üniversitesi Hastanesi Liv Hospital Bahçeşehir
Istanbul, Turkey (Türkiye)