New drug combo shows promise for tough HPV cancers in early trial
NCT ID NCT05826275
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-phase trial tested a new drug called TGN-S11, alone and combined with the immunotherapy Keytruda, in 28 patients with advanced HPV-related cancers that had come back or spread. The main goal was to find a safe dose and see how the body handles the drug. Results will help decide if larger studies are worth doing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TGN-S11 (a small molecule drug) and pembrolizumab (Keytruda, an immunotherapy)
What this could lead to
If successful, this could point toward a new treatment option for people with advanced HPV-related cancers that have not responded to standard therapies.
What could go wrong
This is a very early Phase 1 trial with only 28 participants, so it is primarily testing safety and dosing, not effectiveness. The drug may not work or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope
Duarte, California, 91010, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10128, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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UCSD Moores Cancer Center
La Jolla, California, 92093, United States
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Yale University
New Haven, Connecticut, 06511, United States