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Zapping the Brain's memory center: a new hope for mild cognitive decline?

NCT ID NCT07771036

Symptom relief Sponsor: Shanghai University of Sport Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This trial tests whether a single 20-minute session of a noninvasive brain stimulation technique called temporal interference stimulation, aimed at the hippocampus, can improve memory and the ability to walk and balance while doing another task in older adults with mild cognitive impairment. Participants will receive both active and sham stimulation in random order, with memory tests, balance assessments, and brain scans before and after each session. The goal is to see if this approach can provide immediate benefits for cognitive and motor function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Temporal interference stimulation (TIS), a noninvasive brain stimulation technique targeting the hippocampus
What this could lead to
If effective, this could offer a noninvasive, drug-free way to temporarily improve memory and balance in older adults with mild cognitive impairment, potentially slowing functional decline.
What could go wrong
This is a small, early-stage trial with only 21 participants and a single session of stimulation, so any effects may be short-lived or not generalize. The procedure is generally considered safe, but individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. Aged 65 years or older; 2. Presence of subjective memory complaints; 3. Objective cognitive impairment: screened using the Montreal Cognitive Assessment-Bejingversion (MoCA-BJ). The MoCA-BJ total score is 30 points. For individuals with \<12 years ofeducation, 1 point is added to the raw total score (corrected total score capped at 30 points); acorrected total score \<26 points indicates risk of cognitive impairment; 4. Clinical Dementia Rating (CDR) score of 0.5; 5. Does not meet diagnostic criteria for dementia: Mini-Mental State Examination (MMSE) scores\>18 for illiterate individuals, 221 for those with primary school education, and \>25 for those withjunior high school education or above;6. Retains independent activities of daily living (ADL) and is capable of cooperating with allassessments and interventions.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment (MCI)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanghai University of Sport

    RECRUITING

    Shanghai, Shanghai Municipality, 200438, China

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