Scientists peek inside lungs to see how immune cells react to TB

NCT ID NCT05027958

First seen Nov 06, 2025 · Last updated May 13, 2026 · Updated 27 times

Summary

This study looked at how immune cells in the lungs respond to a TB protein called PPD. Seventeen adults—some with latent TB (no active disease) and some never exposed—received PPD directly into the lung during a bronchoscopy. Researchers then collected lung cells and used PET-CT scans to track immune activity. The goal was to understand tissue-specific immune responses, not to treat or cure TB.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

Conditions

Explore the condition pages connected to this study.