New combo therapy shows promise for tough lung cancers
NCT ID NCT02143466
First seen Oct 31, 2025 · Last updated May 09, 2026 · Updated 22 times
Summary
This study tests whether combining the targeted drug AZD9291 with either AZD6094 or selumetinib is safe and can shrink tumors in people with advanced EGFR-mutant non-small cell lung cancer that has worsened after prior targeted therapy. About 344 adults whose cancer has a specific EGFR mutation and has progressed on drugs like gefitinib or erlotinib are enrolled. The main goal is to find the safest and most effective dose of these combinations.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Research Site
Atlanta, Georgia, 30329, United States
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Research Site
Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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New York, New York, 10065, United States
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Philadelphia, Pennsylvania, 19111, United States
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Nashville, Tennessee, 37232, United States
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Calgary, Alberta, T2N 4N2, Canada
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Edmonton, Alberta, T6G 1Z2, Canada
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Chūōku, 104-0045, Japan
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Research Site
Habikino-shi, 583-8588, Japan
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Hirakata-shi, 573-1191, Japan
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Kashiwa, 227-8577, Japan
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Nagoya, 460-0001, Japan
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Research Site
Nagoya, 464-8681, Japan
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Gdansk, 80-952, Poland
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Research Site
Krakow, 31-202, Poland
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Olsztyn, 10-357, Poland
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Poznan, 60-569, Poland
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Warsaw, 02-781, Poland
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Chelyabinsk, 454087, Russia
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Krasnoyarsk, 660133, Russia
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Moscow, 115478, Russia
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Omsk, 644013, Russia
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Saint Petersburg, 195271, Russia
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Research Site
Saint Petersburg, 197002, Russia
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Research Site
Saint Petersburg, 197022, Russia
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Saint Petersburg, 197342, Russia
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Saint Petersburg, 197758, Russia
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Cheongju-si, 28644, South Korea
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Research Site
Goyang-si, 10408, South Korea
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Seongnam-si, 13620, South Korea
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Research Site
Seoul, 03722, South Korea
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Research Site
Seoul, 05505, South Korea
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Seoul, 6351, South Korea
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Research Site
Kaohsiung City, 82445, Taiwan
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Research Site
Kaohsiung City, 83301, Taiwan
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Research Site
Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taipei, 235, Taiwan
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Kyiv, 03022, Ukraine
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Research Site
Vinnytsia, 21029, Ukraine
Conditions
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