New hope for tough lung cancer? drug combo enters early testing

NCT ID NCT06898957

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 26 times

Summary

This early-stage study tests a combination of three drugs (tarlatamab, YL201, and an anti-PD-L1) in about 200 adults with extensive stage small cell lung cancer that has worsened after initial treatment. The main goal is to check safety and side effects, while also measuring how well the drugs shrink tumors or slow cancer growth. This is not a cure, but aims to control the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Alexandra Hospital

Athens, 11528, Greece
Asan Medical Center

Seoul, 05505, South Korea
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
CHU de Quebec Hopital de l Enfant Jesus

Québec, Quebec, G1J 1Z4, Canada
Centre Leon Berard

Lyon, 69373, France
City of Hope Orange County Lennar Foundation Cancer Center

Irvine, California, 92618, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Clinexpert Kft Bugat Pal Korhaz

Gyöngyös, 3200, Hungary
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
European Interbalkan Medical Center

Thessaloniki, 57001, Greece
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Fujian Cancer Hospital

Fuzhou, 350011, China
Gustave Roussy

Villejuif, 94805, France
Henry Dunant Hospital Center

Athens, 11526, Greece
Hospital Universitari Vall d Hebron

Barcelona, Catalonia, 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, 28222, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Catalonia, 08041, Spain
Iatriko Diavalkaniko Thessalonikis

Thessaloniki, 57001, Greece
Institut Bergonie

Bordeaux, 33000, France
Institut Universitaire du Cancer Toulouse Oncopole

Toulouse, 31059, France
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori

Meldola (FC), 47014, Italy
Istituto di Candiolo Fondazione del Piemonte per l Oncologia IRCCS

Candiolo to, 10060, Italy
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Sanford Oncology Clinic and Pharmacy

Sioux Falls, South Dakota, 54104, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Semmelweis Egyetem

Budapest, 1083, Hungary
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Shandong Cancer Hospital

Jinan, Shandong, 250117, China
Siteman Cancer Center

St Louis, Missouri, 63110, United States
Swedish Medical Center

Seattle, Washington, 98104, United States
Universitaetsklinikum Essen

Essen, 45147, Germany
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
West China Hospital of Sichuan University

Chengdu, Sichuan, 611135, China
Yale New Haven Hospital

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

SMALL CELL LUNG CANCER