Cure My Disease

Don't miss your cure!

 Log in / Sign up

New 3D-Printed ankle bone offers hope for rare condition

NCT ID NCT03965143

Knowledge-focused Sponsor: Kyle Schweser MD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 50 people who have a rare condition where the talus bone in the ankle dies (avascular necrosis). They receive a custom 3D-printed replacement talus, sometimes with a total ankle replacement. Researchers track motion, pain, walking speed, and satisfaction for one year to see how well the implant works compared to older surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients over 18 years of age diagnosed with avascular necrosis of the talar body and amenable to treatment with 3D custom augmentation

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Subjects age 18 years or above at time of screening 2. Condition satisfies requirement for total talus replacement 3. Able to consent and participate in the study 4. No previous history of septic arthritis involving the hindfoot/midfoot 5. Previous ability to ambulate Exclusion Criteria: 1. Active infection, sepsis, osteomyelitis or history of septic arthritis involving the hindfoot/midfoot 2. Unable to consent or participate in the study secondary to mental status 3. Condition does not qualify for a total talus replacement 4. Patients who are pregnant or imprisoned 5. Planned relocation or unable to return for required follow-up visits

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Avascular necrosis of the talus are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

avascular necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Avascular necrosis of the talus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Missouri

    RECRUITING

    Columbia, Missouri, 65212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.