New targeted pill shows promise against rare lung cancer mutation

NCT ID NCT04129502

First seen Apr 06, 2026 · Last updated May 17, 2026 · Updated 10 times

Summary

This study tests a new daily pill, TAK-788, against standard chemotherapy as the first treatment for people with advanced non-small cell lung cancer that has a specific genetic change (EGFR exon 20 insertion). About 354 adults will be randomly assigned to receive either the pill or chemotherapy infusions. The goal is to see if the pill can delay cancer growth better than chemo.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AORN Dei Colli- Ospedale Monaldi Napoli

    Naples, Campania, 80131, Italy

  • AZ Sint-Lucas

    Aalst, Oost-Vlaanderen, 9300, Belgium

  • AdventHealth

    Orlando, Florida, 32804, United States

  • Asan Medical Center - PPDS

    Seoul, 05505, South Korea

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, Tuscany, 56124, Italy

  • Azienda Ospedaliero Universitaria di Parma

    Parma, 43126, Italy

  • Azienda Sanitaria Ospedaliera S Luigi Gonzaga

    Orbassano, Piedmont, 10043, Italy

  • Baskent University Medical Faculty Adana Practice and Research Center

    Yüreğir, Adana, 01120, Turkey (Türkiye)

  • Beijing Cancer Hospital - PPDS

    Beijing, Beijing Municipality, 100142, China

  • Beijing Cancer Hospital - PPDS

    Beijing, 100142, China

  • Beijing Chest Hospital, Capital Medical Univerity

    Beijing, 101149, China

  • Beth Israel Deaconess Medical Center - 330 Brookline Ave

    Boston, Massachusetts, 02115, United States

  • Bioclinic Thessaloniki (Galinos clinic)

    Thessaloniki, 546 29, Greece

  • British Columbia Cancer Agency

    Vancouver, British Columbia, V5Z-4E6, Canada

  • C.H. Regional Reina Sofia - PPDS

    Córdoba, 14004, Spain

  • CHU de Grenoble

    Grenoble, 38043, France

  • CHU de Nantes - Hoptal Nord Laennec

    Nantes, Loire-Atlantique, 44000, France

  • CRLC Val d'Aurelle - Paul Lamarque

    Montpellier, 34298, France

  • Centre Francois Baclesse

    Caen, Calvados, 14076, France

  • Centre Leon Berard

    Lyon, Rhone, 69373, France

  • Centro Di Riferimento Oncologico

    Aviano, Pordenone, 33081, Italy

  • Centro Hospitalar de Lisboa Norte E.P.E Hospital Pulido Valente

    Lisbon, 1769-001, Portugal

  • Centro Hospitalar de Sao Joao, E.P.E.

    Porto, 4200, Portugal

  • Centro Hospitalar do Porto Hospital de Santo Antonio

    Santa Maria da Feira, Aveiro District, 4520-211, Portugal

  • Chi Mei Medical Center, Liouying

    Tainan, 736, Taiwan

  • Chonnam National University Hwasun Hospital

    Jeongnam, 519-763,, South Korea

  • Chungbuk National University Hospital

    Cheongju-si, North Chungcheong, 28644, South Korea

  • City of Hope National Medical Center

    Long Beach, California, 90813, United States

  • Clatterbridge Centre For Oncology

    Bebington, Wirral, CH63 4JY, United Kingdom

  • Cliniques Universitaires Saint-Luc

    Brussels, Brussels Capital, 1200, Belgium

  • Communal Non-profit Enterprise Regional Center of Oncology

    Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine

  • Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

    Dalin, 622, Taiwan

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • E-DA hospital

    Kaohsiung City, 82445, Taiwan

  • Ege University Medical Faculty

    Bornova, İzmir, 35100, Turkey (Türkiye)

  • Ehime University Hospital

    Matsuyama, Ehime, 791-0280, Japan

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042, Australia

  • Fujita Health University Hospital

    Toyoake-Shi, Aiti, 470-1101, Japan

  • GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology)

    Saint Petersburg, Leningradskaya Oblast', 197758, Russia

  • GenesisCare North Shore

    St Leonards, New South Wales, 2065, Australia

  • Grand Hopital de Charleroi asbl

    Charleroi, Hainaut, 6000, Belgium

  • Guangdong Provincial People's Hospital

    Guangzhou, 510080, China

  • Hacettepe University Medical Faculty

    Ankara, 06100, Turkey (Türkiye)

  • Harbin Medical University Tumor Hospital

    Harbin, 150081, China

  • Helios Klinikum Emil Von Behring

    Berlin, 14165, Germany

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450008, China

  • Hopital Calmette

    Lille, Nord, 59037, France

  • Hopital Du Sacre Coeur de Montreal

    Montreal, Quebec, H4J 1C5, Canada

  • Hopital Larrey

    Toulouse, 31059, France

  • Hopital Nord AP-HM

    Marseille, 13915, France

  • Hopital Tenon

    Paris, 75020, France

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Cuf Porto

    Vila Nova de Gaia, Porto District, 4434-502, Portugal

  • Hospital General Universitario de Alicante

    Alicante, 03010, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario A Coruna

    A Coruña, 15006, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital Universitario La Paz - PPDS

    Madrid, 28046, Spain

  • Hospital Universitario Vall d'Hebron - PPDS

    Barcelona, 08035, Spain

  • Hubei Cancer Hospital

    Wuhan, 430079, China

  • ICO lHospitalet Hospital Duran i Reynals

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Icahn School of Medicine at Mount Sinai

    Beijing, China

  • Institut Gustave Roussy

    Villejuif, Val-de-Marne, 94805, France

  • Instituto Europeo Di Oncologia

    Milan, Lombardy, 20141, Italy

  • Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS

    Porto, 4200-072, Portugal

  • Istituto Nazionale Dei Tumori

    Milan, Lombardy, 20133, Italy

  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l - PPDS

    Meldola, Forli-Cesena, 47014, Italy

  • Jilin Cancer Hospital

    Changchun, Jilin, 130012, China

  • Kanagawa Cancer Center

    Yokohama, Kanagawa, 241-0815, Japan

  • Kaohsiung Medical University - Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Karolinska Universitetssjukhuset Solna

    Stockholm, Södermanland County, Sweden

  • Klinik Floridsdorf

    Vienna, 1210, Austria

  • Kurume University Hospital

    Kurume-Shi, Hukuoka, 830-0011, Japan

  • LLC "EuroCityClinic"

    Saint Petersburg, Sankt-Peterburg, 197022, Russia

  • LMU Klinikum der Universitat Munchen

    München, Bavaria, 80336, Germany

  • Leicester General Hospital

    Leicester, LE1 5WW, United Kingdom

  • Massachusetts General Hospital

    Boston, Massachusetts, 02115, United States

  • Miyagi Cancer Center

    Natori-shi, Miyagi, 981-1239, Japan

  • Municipal Non-profit Enterprise "City Clinical Hospital # 4" of Dnipro City Council - PPDS

    Dnipropetrovsk, Dnipropetrovsk Oblast, 49102, Ukraine

  • National Cancer Center

    Goyang, 410769, South Korea

  • National Cancer Center Hospital East

    Kashiwa-Shi, Chiba, 277-0882, Japan

  • National Cancer Centre

    Singapore, 169608, Singapore

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Hospital Organization Hokkaido Cancer Center

    Sapporo, Hokkaido, 003-0804, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • National Taiwan University Hospital - YunLin Branch

    Douliu, 640, Taiwan

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Nouvel Hopital Civil

    Strasbourg, 67091, France

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-0914, Japan

  • Osaka International Cancer Institute

    Chuo Ku, Osaka, 540-0008, Japan

  • Ospedale Santa Maria Delle Croci

    Ravenna, 48121, Italy

  • Pamela Youde Nethersole Eastern Hospital

    Hong Kong, Hong Kong

  • Pius Hospital Oldenburg

    Oldenburg, Lower Saxony, 26121, Germany

  • Prince of Wales Hospital

    Shatin, Hong Kong

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Princess Margaret Hospital

    Toronto, Ontario, M5G2M9, Canada

  • Princess Margaret Hospital

    Kowloon City, Kowloon City, Hong Kong

  • Private Enterprise Private Manufacturing Company Acinus

    Kropyvnytskyi, 25006, Ukraine

  • Pusan National University Hospital

    Busan, 602-739, South Korea

  • Queen Elizabeth Hospital (QEH)

    Hong Kong, Hong Kong

  • Queen Mary Hospital - PPDS

    Hong Kong, Hong Kong

  • Royal Marsden Hospital - Surrey

    Sutton, Surrey, SM2 5PT, United Kingdom

  • SAKARYA University Medical Faculty

    Karaman, Sakarya, 54290, Turkey (Türkiye)

  • Saiseikai Kumamoto Hospital

    Kumamoto, Kumamoto, 861-4101, Japan

  • Saitama Cancer Center

    Komoro, Saitama, 362-0806, Japan

  • Samsung Medical Center PPDS

    Seoul, 06351, South Korea

  • Sarah Cannon Cancer Center

    Nashville, Tennessee, 37203, United States

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System - PPDS

    Seoul, 120-752, South Korea

  • Shanghai East Hospital

    Shanghai, 200123, China

  • Sheba Medical Center - PPDS

    Ramat Gan, 52621, Israel

  • Sichuan Cancer Hospital & Institute

    Chengdu, 610041, China

  • Soroka University Medical Centre

    Beersheba, 84101, Israel

  • Sotiria Chest Hospital of Athens

    Athens, Attica, 11527, Greece

  • Stanford University

    Palo Alto, California, 94304, United States

  • T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin City Hospital

    Kadıköy, Istanbul, 34772, Turkey (Türkiye)

  • Taichung Veterans General Hospital

    Taichung, 407, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • The Cancer Institute Hospital of Japanese Foundation For Cancer Research

    Koto-Ku, Tokyo, 135-0063, Japan

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, 06591, South Korea

  • The Christie NHS Foundation Trust - PPDS

    Manchester, M20 4GJ, United Kingdom

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, 310003, China

  • Thoraxklinik-Heidelberg gGmbH

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • Trakya University Medical Faculty

    Edirne, 22030, Turkey (Türkiye)

  • Tuen Mun Hospital

    Hong Kong, Hong Kong

  • Universitatsklinikum Frankfurt

    Frankfurt am Main, Hesse, 60596, Germany

  • University Clinic Regensburg

    Regensburg, Bavaria, 93053, Germany

  • University College London Hospitals (UCLH)

    London, London, City of, NW1 2PG, United Kingdom

  • University of California Irvine

    Orange, California, 92868, United States

  • University of Maryland Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Virginia Health System

    Charlottesville, Virginia, 22908, United States

  • VU Medisch Centrum

    Amsterdam, North Holland, 1081 HV, Netherlands

  • William Osler Health System

    Brampton, Ontario, L6R 3J7, Canada

Conditions

Explore the condition pages connected to this study.