New pill targets Tough-to-Treat lung cancer mutations

NCT ID NCT02716116

Ongoing Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

Summary

This study tested an oral medication called TAK-788 (mobocertinib) for adults with non-small cell lung cancer (NSCLC). The main goals were to find a safe and effective dose, understand how the body processes the drug, and see if it can shrink tumors, especially in people whose cancer has specific genetic changes (like EGFR or HER2 mutations). Participants took the drug as a capsule, sometimes with other treatments, and were monitored for side effects and tumor response.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

AdventHealth Orlando

Orlando, Florida, 32804, United States
Asan Medical Center

Seoul, 05505, South Korea
Atlantic Health - Morristown Medical Center

Morristown, New Jersey, 07960, United States
Azienda Ospedaliero Universitaria di Parma

Parma, 43126, Italy
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Beijing Chest Hospital

Beijing, Beijing Municipality, 101149, China
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Brookwood Medical Center

Birmingham, Alabama, 35209, United States
Cancer and Blood Specialty Clinic

Los Alamitos, California, 90720, United States
Carolinas Healthcare System

Charlotte, North Carolina, 28204, United States
City of Hope Comprehensive Cancer Center - Duarte

Duarte, California, 91010, United States
Compassionate Cancer Care - Fountain Valley

Fountain Valley, California, 92708, United States
Complejo Hospitalario Universitario A Coruna

A Coruña, LA Coruna, 15006, Spain
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
HELIOS Klinikum Emil von Behring

Berlin, 14165, Germany
Hightower Clinical

Oklahoma City, Oklahoma, 73102, United States
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hubei Cancer Hospital

Wuhan, Hubei, 430079, China
In Situ Global Clinical Trials Network

Manatí, 00674, Puerto Rico
Investigative Clinical Research - Indiana

Indianapolis, Indiana, 46260, United States
Istituto Di Ricovero E Cura A Carattere Scientifico - Istituto Europeo Di Oncologia

Milan, 20141, Italy
Kindai University Hospital

Ōsaka-sayama, Osaka, 589-8511, Japan
Kurume University Hospital

Kurume-shi, Fukuoka, 830-0011, Japan
Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Lumi Research

Houston, Texas, 77090, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospital

Tainan, Tainan CITY, 70403, Taiwan
National Taiwan University Hospital

Taipei, 100, Taiwan
National Taiwan University Hospital - YunLin Branch

Douliu, Yunlin, 640, Taiwan
Oregon Health and Science University

Portland, Oregon, 97239, United States
Pacific Shores Medical Group-Long Beach Elm

Long Beach, California, 90813, United States
Peking University Cancer Hospital/Beijing Cancer Hospital

Beijing, Beijing Municipality, 100036, China
SCRI - Tennessee Oncology - Nashville - Centennial

Nashville, Tennessee, 37203, United States
SLO Oncology and Hematology Health Center

San Luis Obispo, California, 93405, United States
Sendai Kousei Hospital

Sendai, Miyagi, 980-0873, Japan
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital

Seoul, 03722, South Korea
Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, 200433, China
Siteman Cancer Center - Washington University Medical Campus

St Louis, Missouri, 63110, United States
Stanford Cancer Center - Palo Alto

Palo Alto, California, 94305, United States
Swedish Cancer Institute

Seattle, Washington, 98104, United States
Taichung Veterans General Hospital

Taichung, 407, Taiwan
The First Affiliated Hospital, Zhejiang University

Hangzhou, Zhejiang, 310003, China
The Oncology Institute of Hope and Innovation

Whittier, California, 90603, United States
The Oncology Institute of Hope and Innovation - West Tucson

Tucson, Arizona, 85745, United States
The Royal Marsden NHS Foundation Trust

London, England, SW3 6JJ, United Kingdom
The University of Chicago Medicine

Chicago, Illinois, 60637, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Thompson Oncology Group - Knoxville - Downtown

Knoxville, Tennessee, 37916, United States
Thoraxklinik Heidelberg

Heidelberg, Baden-Wurttemberg, 69126, Germany
University of California Irvine Health Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
University of California San Diego Moores Cancer Center

La Jolla, California, 92093, United States
University of Colorado Cancer Center

Aurora, Colorado, 80045, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Virginia Cancer Center

Nashville, Tennessee, 37232, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
Virginia Cancer Specialists - Fairfax Office

Fairfax, Virginia, 22031, United States
Winship Cancer Institute

Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.

CARCINOMA, NON-SMALL-CELL LUNG