New drug shows promise for clearing severe skin plaques

NCT ID NCT06108544

Summary

This large, late-stage study tested whether a new oral drug, TAK-279, could clear or nearly clear the thick, scaly skin patches of moderate-to-severe plaque psoriasis. Over 1,100 participants were randomly assigned to receive TAK-279, a placebo (inactive pill), or an already-approved drug called apremilast for comparison. The main goal was to see how much better TAK-279 worked than the placebo at reducing the severity and extent of psoriasis after 16 weeks.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 4 Medical Clinical Solutions (4MCS) Swinton - PPDS

    Ilford, Essex, IG1 4HP, United Kingdom

  • AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdyni

    Gdynia, Pomeranian Voivodeship, 81-537, Poland

  • AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Katowicach

    Katowice, Silesian Voivodeship, 40-040, Poland

  • AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Warszawie

    Warsaw, Masovian Voivodeship, 02-672, Poland

  • ALLCUTIS Research, LLC.

    Portsmouth, New Hampshire, 03801-03804, United States

  • AP-HM- Hôpital de La Timone

    Marseille, 13885, France

  • Accellacare - North London Clinical Studies Centre

    Northwood, Middlesex, HA6 2RN, United Kingdom

  • Accellacare of Northamptonshire

    Harrow, Middlesex, HA1 3UJ, United Kingdom

  • Accellacare of Yorkshire

    Chorley, Lancashire, PR7 7NA, United Kingdom

  • Adoria

    Riga, Ohio, LV-1011, Latvia

  • Advanced Clinical Research Institute (ACRI) - Florida

    Tampa, Florida, 33607-6429, United States

  • Advanced Medical Research, PC

    Atlanta, Georgia, 30342-1418, United States

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, Jiangsu, 212001, China

  • Alberta DermaSurgery Centre - Probity - PPDS

    Edmonton, Alberta, T6G 1C2 Canada, Canada

  • Allcutis Research LLC

    Beverly, Massachusetts, 01915, United States

  • Allergo-Derm Bakos Kft- Szolnok-Baross utca 20

    Szolnok, Jász-Nagykun-Szolnok, 5000, Hungary

  • Alliance Clinical Trials - Probity - PPDS

    Waterloo, Ontario, N2J 1C4, Canada

  • Ambulatorium Barbara Bazela

    Elblag, 82-300, Poland

  • Ambulatory for Specialized Medical Care- Group Practice in Dermatology - Clinic EuroDerma OOD

    Sofia, Sofia-Grad, 1606, Bulgaria

  • Apex Clinical Research Center

    Mayfield Heights, Ohio, 44124-4005, United States

  • Arlington Research Center

    Arlington, Texas, 76011-3800, United States

  • Austin Institute for Clinical Research, Inc. - Pflugerville - ClinEdge - PPDS

    Pflugerville, Texas, 78660-6148, United States

  • Beacon Clinical Research LLC

    Brockton, Massachusetts, 02301, United States

  • Brunswick Dermatology Centre - Probity - PPDS

    Fredericton, New Brunswick, E3B 1G9, Canada

  • Burke Pharmaceutical Research

    Hot Springs, Arkansas, 71913-6475, United States

  • CCR Ostrava s.r.o.

    Ostrava, Moravskoslezský kraj, 702 00, Czechia

  • CLINTRIAL s.r.o.

    Prague, Praha, Hlavní Mesto, 100 00, Czechia

  • CaRe Clinic-Red Deer

    Red Deer, Alberta, T4N 7C3, Canada

  • Cahaba Dermatology Skin Health Center

    Hoover, Alabama, 35244-2111, United States

  • Canadian Dermatology Centre - Probity - PPDS

    Toronto, Ontario, M3B 0A7, Canada

  • Center For Clinical Studies, LTD. LLP - 451 N Texas Ave

    Webster, Texas, 77598-4927, United States

  • Center For Clinical Studies,LTD. LLP - 451 N Texas Ave

    Webster, Texas, 77598-4927, United States

  • Centre For Dermatology and Cosmetic Surgery - Probity - PPDS

    Richmond Hill, Ontario, L4B 1M5, Canada

  • Centre Hospitalier Le Mans

    Le Mans, Ohio, 72037, France

  • Centro de Investigacion Clínica - CEDIC

    Ciudad Autónomade Buenos Aires, C1060ABN, Argentina

  • Centro de Investigaciones Médicas Tucumán - PPDS

    San Miguel de Tucumán, T4000, Argentina

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    Gdansk, Pomeranian Voivodeship, 80-546, Poland

  • Centrum Medyczne ALL-MED

    Krakow, Lesser Poland Voivodeship, 30-033, Poland

  • Centrum Medyczne Angelius Provita

    Katowice, Silesian Voivodeship, 40-611, Poland

  • Centrum Medyczne Chojnice - PRATIA - PPDS

    Chojnice, Pomeranian Voivodeship, 89-600, Poland

  • Centrum Terapii Wspolczesnej

    Lódz, Lódzkie, 90-338, Poland

  • Centrum Uslug Medycznych MaxMed

    Bochnia, 32-700, Poland

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029, China

  • ClinMedica Research

    Skierniewice, Lódzkie, 96-100, Poland

  • ClinOhio Research Services

    Columbus, Ohio, 43213-4445, United States

  • Clinical Research Group Sp. z o.o

    Warsaw, Masovian Voivodeship, 01-142, Poland

  • Conexa Investigación Clínica S.A.

    Buenos Aires, C1012, Argentina

  • Cumberland Skin Center for Clinical Research - Objective Health - PPDS

    Hermitage, Tennessee, 37076-3497, United States

  • DS Research - 1005 E. Lewis & Clark Pkwy Indiana Location

    Clarksville, Indiana, 47129-2201, United States

  • DS Research of Kentucky

    Louisville, Kentucky, 40241-6162, United States

  • David Fivenson MD Dermatology PLLC

    Ann Arbor, Michigan, 48103-9746, United States

  • Debreceni Egyetem Klinikai Kozpont Nagyerdei Campus

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Derm Research Center of NY

    Stony Brook, New York, 11790, United States

  • DermEdge Research - Probity - PPDS

    Mississauga, Ontario, L4Y 4C5, Canada

  • DermEffects - Probity - PPDS

    London, Ontario, N6H 5L5, Canada

  • Dermamedica, s.r.o. - Kozni Ambulance Nachod

    Náchod, Královéhradecký kraj, 547 01, Czechia

  • Dermatologikum Hamburg

    Hamburg, 20354, Germany

  • Dermatology & Advanced Aesthetics

    Lake Charles, Louisiana, 70605-1213, United States

  • Dermatology Clinical Research Center of San Antonio

    San Antonio, Texas, 78229-3409, United States

  • Dermatology Institute and Skin Care Center

    Santa Monica, California, 90404-2216, United States

  • Dermatology Research Institute, Inc. - Probity - PPDS

    Calgary, Alberta, T3A 2N1, Canada

  • Dermatrials Research

    Hamilton, Ontario, L8N 1Y2, Canada

  • Dermedic Jacek Zdybski

    Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland

  • DermoDent Centrum Medyczne Aldona Czajkowska Rafał Czajkowski, s.c.

    Osielsko, 86-031, Poland

  • Dermskin s.r.o.

    Olomouc, Olomoucký kraj, 779 00, Czechia

  • Diagnostic Consultative Center Sveti Georgi EOOD

    Haskovo, 6300, Bulgaria

  • Diagnostic Consultative Center XXVIII - Sofia - EOOD

    Sofia, Sofia-Grad, 1592, Bulgaria

  • Diagnostic Consultative Centre - Focus-5 - LZIP EOOD

    Sofia, Sofia-Grad, 1463, Bulgaria

  • Diagnostic and Consulting Center Aleksandrovska EOOD

    Sofia, Sofia-Grad, 1431, Bulgaria

  • Diamond Clinic

    Krakow, 31-559, Poland

  • Divine Dermatology and Aesthetics, LLC

    Atlanta, Georgia, 30315-2042, United States

  • Dr. S. K. Siddha Medicine Professional Corporation - Probity - PPDS

    Richmond Hill, Ontario, L4C 9M7, Canada

  • Duke Dermatology Clinic

    Durham, North Carolina, 27710-4000, United States

  • ETG Lublin - PPDS

    Lublin, 20-314, Poland

  • ETG Siedlce - PPDS

    Siedlce, Masovian Voivodeship, 08-110, Poland

  • ETG Warszawa - PPDS

    Warsaw, Masovian Voivodeship, 02-677, Poland

  • ETYKA Osrodek Badan Klinicznych

    Olsztyn, 10-117, Poland

  • FXM Research Miramar

    Miramar, Florida, 33027-4714, United States

  • Fachklinik Bad Bentheim

    Bad Bentheim, Lower Saxony, 48455, Germany

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34, Czechia

  • First Hospital of Shanxi Medical University

    Taiyuan, Shanxi, 030001, China

  • First OC Dermatology Research Inc.

    Fountain Valley, California, 92708-3701, United States

  • Florida Academic Centers Research

    Miami, Florida, 33136-1003, United States

  • FutureMeds - Berlin - PPDS

    Berlin, 10629, Germany

  • FutureMeds - Targowek - PPDS

    Warsaw, Masovian Voivodeship, 03-291, Poland

  • GCM Medical Group, PSC -62 Calle Jose Marti

    San Juan, 00909-3004, Puerto Rico

  • Globe Badania Kliniczne Spólka z o.o. - Klodzko

    Klodzko Dolnoslaskie, 57-300, Poland

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510080, China

  • HaEmek Medical Center

    Afula, 18101, Israel

  • Hadassah Medical Center- Ein Kerem - PPDS

    Jerusalem, Jerusalem, 9112002, Israel

  • Health Center 4, Center of Diagnostics

    Riga, LV-1003, Latvia

  • Health Center 4, Clinic of Dermatology

    Riga, LV-1013, Latvia

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, 450003, China

  • Hospital A.Syggros

    Athens, Attica, 161 21, Greece

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Of Skin And Venereal Diseases of Thessaloniki

    Thessaloniki, 546 43, Greece

  • Hospital Universitario Germans Trias i Pujol

    Badalona, Barcelona, 08915, Spain

  • Hospital Universitario La Paz - PPDS

    Madrid, 28046, Spain

  • Hospital Universitario de Gran Canaria Doctor Negrin

    Las Palmas de Gran Canaria, 35010, Spain

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • Hospital de Manises

    Manises, Valencia, 46940, Spain

  • Houston Center for Clinical Research, LLC

    Sugar Land, Texas, 77479-1001, United States

  • Huashan Hospital Fudan University - PPDS

    Shanghai, 200040, China

  • Hôpital Charles Nicolle-1 Rue de Germont

    Rouen, 76031, France

  • Instituto de Neumonologia y Dermatologia

    Buenos Aires, C1425BEA, Argentina

  • J. Kisis

    Riga, LV-1003, Latvia

  • Johnson Dermatology Clinic

    Fort Smith, Arkansas, 72916-6103, United States

  • Klinische Forschung Dresden GmbH (KFGN) - PRATIA - PPDS

    Dresden, Saxony, 01069, Germany

  • Krakowskie Centrum Medyczne - FutureMeds - PPDS

    Krakow, Lesser Poland Voivodeship, 31-501, Poland

  • Lawrence J Green, MD LLC

    Rockville, Maryland, 20850-6363, United States

  • Lenus Research & Medical Group

    Sweetwater, Florida, 33172-2741, United States

  • Lima's Excellence In Allergy And Dermatology Research (Leader) Inc. - Probity - PPDS

    Hamilton, Ontario, L8L 3C3, Canada

  • Long Beach Research Institute, LLC

    Long Beach, California, 90805-4587, United States

  • Luxderm Specjalistyczny Gabinet Dermatologiczny Dorota Krasowska

    Lublin, Lublin Voivodeship, 20-573, Poland

  • Lynderm Research Inc - Probity - PPDS

    Markham, Ontario, L3P 1X3, Canada

  • MBAL Skin Systems, Doganovo

    Elin Pelin, Sofia, 2115, Bulgaria

  • MC Comac Medical - IRN - PPDS

    Sofia, Sofia-Grad, 1612, Bulgaria

  • MCM Krakow - PRATIA - PPDS

    Krakow, 30-727, Poland

  • MICS Centrum Medyczne Torun - MICS - PPDS

    Torun, Ohio, 87-100, Poland

  • Medical Center Asklepii OOD

    Dupnitsa, Kyustendil, 2600, Bulgaria

  • Medical Center Exacta Medica - Vasil Levski 60

    Pleven, 5801, Bulgaria

  • Medical Center Hera EOOD

    Sofia, Sofia-Grad, 1510, Bulgaria

  • Medical Center Medconsult Pleven OOD

    Pleven, 5800, Bulgaria

  • Medical Center Unimed EOOD

    Sevlievo, Gabrovo, 5400, Bulgaria

  • Medical Dermatology Specialists

    Phoenix, Arizona, 85006-2722, United States

  • Medizinisches Versorgungszentrum DermaKiel GmbH

    Kiel, 24148, Germany

  • Metropolis Dermatology Downtown LA - Probity - PPDS

    Los Angeles, California, 90017-5310, United States

  • Military Medical Academy Multiprofile Hospital for Active Treatment - Sofia

    Sofia, Sofia-Grad, 1606, Bulgaria

  • Minnesota Clinical Study Center

    Fridley, Minnesota, 55432-3134, United States

  • Modern Research Associates

    Dallas, Texas, 75231-6077, United States

  • Montefiore Dermatology - BRANY - PPDS

    The Bronx, New York, 10467-1402, United States

  • Mount Sinai Doctors -234 E 85th St

    New York, New York, 10029-6504, United States

  • Multiprofile Hospital For Active Treatment Dr Tota Venkova

    Gabrovo, 5300, Bulgaria

  • Multiprofile Hospital for Active Treatment - Dobrich AD

    Dobrich, 9300, Bulgaria

  • NZOZ Osteo Medic SC Artur Racewicz Jerzy Supronik

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • Nemocnice AGEL Novy Jicin a.s

    Nový Jičín, Moravskoslezský kraj, 741 01, Czechia

  • Noble Clinical Research

    Tucson, Arizona, 85704-7892, United States

  • North Texas Center for Clinical Research

    Frisco, Texas, 75034, United States

  • NorthShore Medical Group Dermatology - Skokie

    Skokie, Illinois, 60077-1049, United States

  • Northridge Clinical Trials

    Northridge, California, 91325-4122, United States

  • Oakland Hills Dermatology - 3400 Auburn Rd

    Auburn Hills, Michigan, 48326-3396, United States

  • Olympian Clinical Research - 6331 Memorial Hwy

    Tampa, Florida, 33615, United States

  • Oregon Medical Research Center PC

    Portland, Oregon, 97239-4501, United States

  • Oshawa Clinic-117 King St

    Oshawa, Ontario, L1R 1R7, Canada

  • Ostrowieckie Centrum Medyczne

    Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, 564 29, Greece

  • Praglandia s.r.o.

    Prague, Ohio, 150 00, Czechia

  • Pratia Brno s.r.o. - PRATIA - PPDS

    Brno, South Moravian, 602 00, Czechia

  • Pratia Pardubice a.s. - PRATIA - PPDS

    Pardubice, 530 02, Czechia

  • Praxis fur Dermatologie and Venerologie

    Dresden, Saxony, 01097, Germany

  • Pro Familia Altera Sp. z o.o.

    Katowice, Silesian Voivodeship, 40-648, Poland

  • Prof. MUDr. Petr Arenberger, DrSc. - CRC - PPDS

    Prague, 110 00, Czechia

  • Psoriasis Treatment Center of Central New Jersey

    East Windsor, New Jersey, 08520, United States

  • Pécsi Tudomanyegyetem - Vasvari Pal u.

    Pécs, 7632, Hungary

  • RCMed Oddzial Sochaczew

    Sochaczew, Masovian Voivodeship, 96-500, Poland

  • Rabin Medical Center - PPDS

    Petah Tikva, 49100, Israel

  • Revival Research Corporation - Florida - ClinEdge - PPDS

    Doral, Florida, 33122-1902, United States

  • Riga 1st Hospital

    Riga, LV-1001, Latvia

  • Royalderm

    Warsaw, Poland

  • SKiN Centre for Dermatology - Peterborough - Probity - PPDS

    Peterborough, Ontario, K9J 1Z2, Canada

  • SRH Wald-Klinikum Gera GmbH

    Gera, Thuringia, 07548, Germany

  • STAT Research S.A.

    Buenos Aires, C1023AAB, Argentina

  • Sadick Research Group

    New York, New York, 10075-0385, United States

  • Salford Royal Hospital - PPDS

    Salford, Lancashire, M6 8HD, United Kingdom

  • San Marcus Research Clinic Inc

    Miami Lakes, Florida, 33014-5602, United States

  • Semigallia

    Kuldīga, LV-3301, Latvia

  • Siena Medical Research

    Westmount, Quebec, H3Z 2S6, Canada

  • Sir Run Run Shaw Hospital Zhejiang University School of Medicine - Qingchun Campus

    Hangzhou, Zhejiang, 310016, China

  • Skin Care Physicians of Georgia

    Macon, Georgia, 31217-3861, United States

  • Skin Sciences, PLLC

    Louisville, Kentucky, 40217-1444, United States

  • Skin Specialists PC

    Omaha, Nebraska, 68144, United States

  • Skinsense Medical Research - 411 2nd Ave N - Probity - PPDS

    Saskatoon, Saskatchewan, S7K 0H6, Canada

  • Smite Aija doctor practice in dermatology, venerology

    Talsi, Talsu Aprinkis, LV-3201, Latvia

  • Solumed Centrum Medyczne

    Poznan, Greater Poland Voivodeship, 60-101, Poland

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz

    Kaposvár, Somogy County, 7400, Hungary

  • St Luke's Hospital

    Bradford, West Yorkshire, BD5 0NA, United Kingdom

  • Szegedi Tudomanyegyetem

    Szeged, Csongrád megye, 6720, Hungary

  • TCR Medical Corporation

    San Diego, California, 92123-1523, United States

  • Tel Aviv Sourasky Medical Center Ichilov - PPDS 27004

    Tel Aviv, Tel Aviv, 64239, Israel

  • Tennessee Clinical Research Center

    Nashville, Tennessee, 37215-2888, United States

  • Texas Dermatology and Laser Specialists

    San Antonio, Texas, 78218-3128, United States

  • The Centre for Clinical Trials Inc. - Probity - PPDS

    Oakville, Ontario, L6J 7W5, Canada

  • The Chaim Sheba Medical Center - PPDS

    Ramat Gan, Tel Aviv, 52621, Israel

  • The First Affiliated Hospital With Nanjing Medical University(Jiangsu Province Hospital)

    Nanjing, Jiangsu, 210029, China

  • The Second Affiliated Hospital of Kunming Medical University

    Kunming, Yunnan, 650000, China

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330008, China

  • The Skin Surgery Center for Clinical Research - Objective Health - PPDS

    Winston-Salem, North Carolina, 27103-7109, United States

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan, 410013, China

  • Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430030, China

  • Toronto Research Centre - Probity - PPDS

    Toronto, Ontario, M3H 5Y8, Canada

  • Total Dermatology

    Birmingham, Alabama, 35205, United States

  • Twoja Przychodnia Nowosolskie Centrum Medyczne sp. z o.o

    Nowa Sól, Lubusz Voivodeship, 67-100, Poland

  • Twoja Przychodnia PCM

    Poznan, Greater Poland Voivodeship, 61-293, Poland

  • UNISON Clinical Trials (Shahram Jacobs md inc.)

    Encino, California, 91436-2428, United States

  • UT Physicians Dermatology - Bellaire Station

    Bellaire, Texas, 77401-3535, United States

  • University Clinical Trials

    San Diego, California, 92123, United States

  • University General Hospital ''ATTIKON''

    Chaïdári, Attica, 124 62, Greece

  • University Hospital of Ioannina

    Loannina, Loannina, 455 00, Greece

  • University Multiprofile Hospital for Active Treatment -Dr. Georgi Stranski -Gen. V. Vazov Str 91

    Pleven, Bulgaria

  • University of Michigan Hospital - 1500 E Medical Center Dr

    Ann Arbor, Michigan, 48109-5360, United States

  • University of Pittsburgh Medical Center-3601 5th Ave

    Pittsburgh, Pennsylvania, 15213-3403, United States

  • VIDA Dermatology - Probity - PPDS

    Edmonton, Alberta, T6H 4J8, Canada

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz

    Szombathely, Vas County, 9700, Hungary

  • Velocity Clinical Research, High Wycombe - PPDS

    High Wycombe, Buckinghamshire, HP11 2QW, United Kingdom

  • Velocity Clinical Research, North London - PPDS

    London, Middlesex, N12 8BU, United Kingdom

  • Veseliba un estetika

    Riga, LV-1009, Latvia

  • Virginia Clinical Research - 6160 Kempsville Cir

    Norfolk, Virginia, 23507, United States

  • Vivida Dermatology - Flamingo Rd - Probity - PPDS

    Las Vegas, Nevada, 89119-5190, United States

  • Wake Forest Baptist Health Department of Dermatology - 4618 Country Club Rd

    Winston-Salem, North Carolina, 27157-0001, United States

  • West China Hospital Sichuan University

    Chengdu, Sichuan, 610041, China

  • Whipps Cross Hospital

    London, London, City of, E11 1NR, United Kingdom

  • Wiseman Dermatology Research Inc. - Probity - PPDS

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Wright State Physicians

    Fairborn, Ohio, 45324, United States

  • WroMedica

    Wroclaw, Lower Silesian Voivodeship, 51-685, Poland

  • XLR8 Medical Research - Probity - PPDS

    Windsor, Ontario, N8X 3V6, Canada

  • Zenith Research, Inc.

    Beverly Hills, California, 90211-1705, United States

  • dermMEDICA Sp. z o.o

    Wroclaw, 51-503, Poland

Conditions

Explore the condition pages connected to this study.