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New drug combo aims to tackle tough lymphoma

NCT ID NCT05222555

Ongoing Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a modified intravenous dosing schedule of tafasitamab combined with oral lenalidomide in 53 adults with relapsed or refractory diffuse large B-cell lymphoma who are not eligible for a stem cell transplant. The main goal is to evaluate safety and how the drug moves through the body, with a secondary focus on tumor response. It is an early-phase, open-label trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tafasitamab (a targeted antibody) and lenalidomide (an immune-modulating drug)
What this could lead to
If successful, this could offer a new treatment option for people with relapsed or refractory diffuse large B-cell lymphoma who cannot have a stem cell transplant.
What could go wrong
This is an early-phase trial with only 53 participants, so results may not apply broadly. Side effects from the drug combination could be significant, and the modified dosing may not improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B-CELL LYMPHOMA

Contacts and locations

Locations

  • ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda

    Milan, Lombardy, 20162, Italy

  • ASST di Monza - Azienda Ospedaliera San Gerardo

    Monza, Monza E Brianza, 20900, Italy

  • Asan Medical Center - PPDS

    Seoul, 5505, South Korea

  • Azienda Ospedaliera di Perugia

    Perugia, Umbria, 6122, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, Tuscany, 56127, Italy

  • CHU Nantes

    Nantes, Loire-Atlantique, 44000, France

  • CHU de Poitiers

    Poitiers, Vienne, 86021, France

  • Centre Hospitalier Le Mans

    Le Mans, Sarthe, 72000, France

  • Centre Hospitalier Universitaire Grenoble Alpes - Hopital Albert Michallon

    Grenoble, Isère, 38043, France

  • Centrum Medyczne Poznan - PRATIA - PPDS

    Skórzewo, Greater Poland Voivodeship, 60-185, Poland

  • Chonbuk National University Hospital

    Jeonju, 54907, South Korea

  • Complejo Asistencial Universitario de Salamanca - H. Clinico

    Salamanca, 37007, Spain

  • Daegu Catholic University Medical Center

    Daegu, 42472, South Korea

  • Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii

    Wroclaw, Lower Silesian Voivodeship, 53-439, Poland

  • Dong-A University Medical Center

    Busan, 49201, South Korea

  • Fakultni nemocnice Brno

    Brno, 625 00, Czechia

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34, Czechia

  • Fakultni nemocnice Ostrava

    Ostrava, 708 52, Czechia

  • Fakultni nemocnice v Motole

    Prague, 150 06, Czechia

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

    Milan, Lombardy, 20122, Italy

  • Fondazione IRCCS Policlinico San Matteo di Pavia

    Pavia, Lombardy, 27100, Italy

  • Fondazione del Piemonte per l'Oncologia (IRCCS)

    Candiolo, Piedmont, 10060, Italy

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Hadassah Medical Center - Hadassah Ein Kerem

    Jerusalem, 91120, Israel

  • Hanyang University Medical Center

    Seoul, 4763, South Korea

  • Hospital Son Llatzer

    Palma de Mallorca, Balearic Islands, 7198, Spain

  • Hospital U. Infanta Leonor

    Madrid, 28031, Spain

  • Hospital U. Quironsalud Madrid

    Madrid, 28223, Spain

  • Hospital U. Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital U. Virgen del Rocio

    Seville, 41013, Spain

  • Hospital Universitari La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • ICO l'Hospitalet - Hospital Duran i Reynals

    L'Hospitalet de Llobregat, 8907, Spain

  • Institut Catala d'Oncologia Girona

    Girona, 17007, Spain

  • Klinikum Wels Grieskirchen

    Wels, Upper Austria, 4600, Austria

  • Kosin University Gospel Hospital

    Busan, 49267, South Korea

  • Lady Davis Carmel Medical Center

    Haifa, 34362, Israel

  • MD Anderson Madrid

    Madrid, 28033, Spain

  • Morristown Memorial Hospital

    Morristown, New Jersey, 07960-6459, United States

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • Nasz Lekarz Osrodek Badan Klinicznych

    Torun, 87-100, Poland

  • Ospedale Santa Maria Delle Croci

    Ravenna, Emilia-Romagna, 48121, Italy

  • Pratia MCM Krakow

    Krakow, Lesser Poland Voivodeship, 30-510, Poland

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • SP ZOZ Szpital Uniwersytecki w Krakowie

    Krakow, 31-501, Poland

  • SPZOZ MiSWiA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie

    Olsztyn, 10-228, Poland

  • Shamir Medical Center Assaf Harofeh

    Be’er Ya‘aqov, 70300, Israel

  • Soroka University Medical Centre

    Beersheba, Southern District, 84101, Israel

  • Szpital Wojewodzki w Opolu

    Opole, Opole Voivodeship, 45-061, Poland

  • Szpitale Pomorskie Sp. z o. o.

    Gdynia, 81-519, Poland

  • Texas Oncology-Baylor Charles A. Sammons Cancer Center - USOR

    Dallas, Texas, 75246-2092, United States

  • The Catholic University of Korea, St. Vincent's Hospital

    Suwon, Gyeonggido, 16247, South Korea

  • The Catholic University of Korea, Yeouido St. Mary's Hospital

    Seoul, 7345, South Korea

  • UK St. Pölten

    Sankt Pölten, Lower Austria, 3100, Austria

  • Ulsan University Hospital

    Ulsan, 44033, South Korea

  • Universitatsklinikum Salzburg

    Salzburg, 5020, Austria

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu

    Wroclaw, Lower Silesian Voivodeship, 50-367, Poland

  • Vista Oncology

    Olympia, Washington, 98506, United States

  • Vseobecna Fakultni Nemocnice V Praze

    Prague, 128 08, Czechia

  • Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

    Lodz, 93-513, Poland

  • Yeungnam University Hospital

    Daegu, 42415, South Korea

  • ZIV Medical Center

    Safed, 13100, Israel

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