Could a clot from your own blood help bones heal better after a tooth pull?
NCT ID NCT07712497
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This study tests whether a special material made from a person's own blood, called titanium-prepared platelet-rich fibrin (T-PRF), can improve bone healing after a tooth is pulled. Thirty healthy adults who need a tooth extraction and later a dental implant are randomly assigned to receive either T-PRF placed in the socket or standard care (natural healing). After three months, 3D X-ray scans measure how much new bone has filled the socket. The goal is to see if T-PRF helps preserve bone for a stronger foundation for future implants.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a biological material made from the participant's own blood, called titanium-prepared platelet-rich fibrin (T-PRF), placed into the tooth socket after extraction
- What this could lead to
- If effective, T-PRF could become a simple, low-cost way to improve bone healing after tooth extraction, making future dental implants easier and more successful.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The benefit over natural healing may be small or absent.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Mar 2023
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 to 65 years. * Systemically healthy individuals. * Indication for tooth extraction followed by implant placement. * Adequate bone volume for future implant placement without the need for advanced augmentation procedures. * Good oral hygiene (Plaque Index ≤1.5) * Ability and willingness to provide written informed consent. Exclusion Criteria: * Current smokers. * Pregnant or breastfeeding women. * Uncontrolled systemic disease or diabetes mellitus. * Use of medications known to affect bone metabolism. * History of head and neck radiotherapy or chemotherapy. * Acute infection, periapical lesions, alveolar bone pathology, or socket defects at the extraction site. * Severe periodontal destruction requiring extensive augmentation procedures. * Inability or unwillingness to attend scheduled follow-up visits.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Periodontology, Faculty of Dentistry, Eskişehir Osmangazi University
Eskişehir, 26140, Turkey (Türkiye)
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