New hope for HER2-positive lung cancer: targeted drug plus immunotherapy enters human testing

NCT ID NCT04686305

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 31 times

Summary

This study tests a targeted cancer drug (trastuzumab deruxtecan) combined with immunotherapy, with or without chemotherapy, as a first treatment for people with advanced non-small cell lung cancer that has high levels of a protein called HER2. The main goal is to check safety and find the best dose. About 304 participants will take part. This is an early-phase trial, so it focuses on safety first, but researchers will also measure how well the tumors shrink.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

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WITHDRAWN

Duarte, California, 91010, United States
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Newport Beach, California, 92663, United States
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RECRUITING

Orange, California, 92868, United States
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Santa Rosa, California, 95403, United States
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Westwood, Kansas, 66205, United States
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RECRUITING

Baltimore, Maryland, 21287, United States
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Detroit, Michigan, 48201, United States
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Buffalo, New York, 14263, United States
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New York, New York, 10029, United States
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WITHDRAWN

The Bronx, New York, 10461, United States
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RECRUITING

Houston, Texas, 77030, United States
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RECRUITING

Fairfax, Virginia, 22031, United States
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WITHDRAWN

Tacoma, Washington, 98405, United States
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TERMINATED

Adelaide, 5000, Australia
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WITHDRAWN

Heidelberg, 3084, Australia
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RECRUITING

Nedlands, 6009, Australia
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COMPLETED

Edegem, 2650, Belgium
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RECRUITING

Barretos, 14784-400, Brazil
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Porto Alegre, 90035-903, Brazil
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RECRUITING

São Paulo, 05652-900, Brazil
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Winnipeg, Manitoba, R3E 0V9, Canada
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London, Ontario, N6A 5W9, Canada
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RECRUITING

Montreal, Quebec, H3T 1E2, Canada
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NOT_YET_RECRUITING

Changchun, 130000, China
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NOT_YET_RECRUITING

Chengdu, 610041, China
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NOT_YET_RECRUITING

Fuzhou, 350011, China
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NOT_YET_RECRUITING

Shandong, China
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RECRUITING

Shanghai, 200433, China
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NOT_YET_RECRUITING

Zhengzhou, 450000, China
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WITHDRAWN

Bordeaux, 33075, France
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RECRUITING

Dijon, 21079, France
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RECRUITING

Pierre-Bénite, 69495, France
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Saint-Herblain, 44800, France
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Villejuif, 94805, France
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RECRUITING

Kfar Saba, 4428164, Israel
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RECRUITING

Tel Litwinsky, 52620, Israel
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COMPLETED

Milan, 20133, Italy
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RECRUITING

Milan, 20162, Italy
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Monza, 20052, Italy
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Naples, 80131, Italy
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WITHDRAWN

Padova, 35128, Italy
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RECRUITING

George Town, 10450, Malaysia
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RECRUITING

Kuala Lumpur, 59100, Malaysia
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RECRUITING

Kuala Selangor, 62250, Malaysia
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RECRUITING

Kuching, 93586, Malaysia
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COMPLETED

Amsterdam, 1066 CX, Netherlands
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RECRUITING

Bacolod, 6100, Philippines
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WITHDRAWN

Cebu City, 6000, Philippines
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WITHDRAWN

City of Taguig, 1634, Philippines
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TERMINATED

Davao City, PH-8000, Philippines
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TERMINATED

Manila, 1000, Philippines
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WITHDRAWN

Manila, 1015, Philippines
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RECRUITING

Quezon City, 1100, Philippines
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RECRUITING

Quezon City, 1112, Philippines
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TERMINATED

San Juan City, 1500, Philippines
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RECRUITING

Gdansk, 80-214, Poland
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SUSPENDED

Krakow, 30-727, Poland
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RECRUITING

Olsztyn, 10-357, Poland
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TERMINATED

Tomaszów Mazowiecki, 97-200, Poland
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RECRUITING

Warsaw, 02-781, Poland
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COMPLETED

Singapore, 119228, Singapore
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COMPLETED

Singapore, 168583, Singapore
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COMPLETED

Singapore, 308433, Singapore
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RECRUITING

Cheongju-si, 28644, South Korea
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RECRUITING

Goyang-si, 10408, South Korea
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RECRUITING

Jinju, 52727, South Korea
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RECRUITING

Seoul, 03722, South Korea
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WITHDRAWN

Seoul, 05505, South Korea
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RECRUITING

Seoul, 06351, South Korea
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WITHDRAWN

Badalona, 08013, Spain
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Madrid, 28041, Spain
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Seville, 41013, Spain
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WITHDRAWN

Valencia, 46010, Spain
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RECRUITING

Kaohsiung City, 833, Taiwan
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Taichung, 402, Taiwan
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RECRUITING

Taichung, 40705, Taiwan
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RECRUITING

Tainan, 70403, Taiwan
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RECRUITING

Taipei, 100, Taiwan
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RECRUITING

Taipei, 11217, Taiwan
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RECRUITING

Taipei, 235, Taiwan
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RECRUITING

Taoyuan, 333, Taiwan
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RECRUITING

Bangkok, 10300, Thailand
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COMPLETED

Bangkok, 10330, Thailand
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COMPLETED

Hat Yai, 90110, Thailand
Research Site
COMPLETED

Khon Kaen, 40002, Thailand
Research Site
NOT_YET_RECRUITING

Muang, 22000, Thailand
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RECRUITING

Muang, 50200, Thailand
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RECRUITING

Ankara, 06800, Turkey (Türkiye)
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RECRUITING

Ankara, 6200, Turkey (Türkiye)
Research Site
ACTIVE_NOT_RECRUITING

Bornova-Izmir, 35100, Turkey (Türkiye)
Research Site
RECRUITING

Istanbul, 31755, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER