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Brain cancer immune therapy trial pulled before it started

NCT ID NCT05341947

Disease control Sponsor: Jeremy Rudnick, M.D Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This was a very early phase 1 trial that planned to test a personalized immune cell therapy for people with recurrent glioblastoma, an aggressive brain cancer. The treatment involved taking a patient's own T cells, activating them in a lab to target cancer stem cells, and giving them back intravenously. However, the study was withdrawn before enrolling any participants, so no results are available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
activated T cells

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Recurrent glioblastoma * HLA-A1 and HLA-A2 positive * Complete resection of tumor Exclusion Criteria: * Clinically significant pulmonary, cardiac or other systemic disease * Presence of an acute infection requiring active treatment with antibiotics/antivirals; prophylactic administration is allowed. * Known human immunodeficiency virus positivity or acquired immunodeficiency syndrome related illness or other serious medical condition. * Known history of Hepatitis B or Hepatitis C * Allergy to Dimethyl sulfoxide (DMSO) * Allergy to gentamicin

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Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma) brain cancer ependymoma glioblastoma glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent glioblastoma

Contacts and locations

Locations

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.