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A new kind of MRI aims to watch brain connections change in seconds

NCT ID NCT01686516

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study tests whether a type of diffusion MRI can detect rapid, activity-driven changes in brain connections — called synaptic plasticity — during visual stimulation. Researchers will scan healthy adults aged 20–30 and 60–80 to compare how the aging brain responds. If successful, the method could offer a new way to study brain health without using radioactive tracers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If diffusion MRI can reliably track synaptic plasticity, it could become a new tool for studying brain aging and early signs of decline.
What could go wrong
This is a small, early-stage methodological study in healthy volunteers. The technique may not prove sensitive or specific enough for clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

35 people

The number who actually took part.

Started

Dec 2011

Finished

Sep 2012

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

population free of any psychological or organic troubles, with no metal inclusions for MRI convenience.

Ages

20 to 80 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ages 20-30 years * 60-80 years Exclusion Criteria: * psychological or organic trouble

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain aging

Contacts and locations

Locations

  • Inserm U 825

    Toulouse, France, 31059, France

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