Can a Non-Opioid drug match oxycodone for nail surgery pain?
NCT ID NCT07820969
First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time
Summary
Researchers at the University of Miami compare three ways to control pain after nail unit procedures: suzetrigine, a combination of oxycodone and acetaminophen, and alternating acetaminophen and ibuprofen. The study enrolls 45 adults undergoing these procedures. Participants take one of the three regimens for five days and rate their pain on a 0 to 10 scale. The goal is to see which approach eases post-operative pain most effectively.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- suzetrigine, an experimental non-opioid pain drug, compared with oxycodone plus acetaminophen and with alternating acetaminophen and ibuprofen
- What this could lead to
- If suzetrigine controls pain as well as opioids after nail procedures, it could offer a non-addictive option for short-term surgical pain.
- What could go wrong
- This is a small pilot study of 45 people at one clinic, so it may not show a clear difference between the three pain regimens or predict how they work in larger, more varied groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 45 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * All patients age 18+ able to understand and provide written consent in English or Spanish who present to Dr. Brian Morrison's clinic at the University of Miami and are undergoing a nail unit procedure. Exclusion Criteria: * Patients under the age of 18 or adults unable to consent. * Patients who are pregnant or incarcerated.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Miami, Phillip Frost Dermatology Clinic
Miami, Florida, 33136, United States