5-Minute MRI could spot brain changes in rare disorder
NCT ID NCT04517565
First seen Jun 27, 2026 · Last updated Aug 20, 2026 · Updated 2 times
Summary
This study tests a new, fast MRI method that takes about 5 minutes, uses no contrast dye, and often no sedation, even in children. Researchers will scan 80 people with Sturge-Weber syndrome (ages 3 months to 30 years) to see if this quick MRI can accurately detect brain abnormalities. They will also study how advanced MRI scans relate to thinking and motor skills, with the goal of guiding future treatments to reduce learning problems.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2020
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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3 months to 30 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects with Sturge-Weber syndrome (SWS): 1. Age 3 months - 30 years; 2. Presence of a facial port-wine birthmark (PWB) indicating a risk for SWS and/or evidence of SWS brain involvement based on the presence of one or more intracranial SWS brain abnormalities from previous clinical imaging (MRI or computed tomography) scan(s) with or without a facial PWB. SWS brain abnormalities can include both brain vascular and/or parenchymal abnormalities (including atrophy, calcification, etc.); 3. In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language. 2. Healthy control subjects: 1. Age 3 years - 30 years; 2. No history of neurological or psychiatric disorder Exclusion Criteria: For all subjects: 1. Metal in the head or mouth that would preclude safe, artifact-free MRI scanning; or any other metal or electronic device contraindicated for MRI scanning. 2. History of severe claustrophobia, precluding staying still in the scanner for up to 30 minutes. 3. Pregnancy (pregnant women will be scheduled for the study after delivery). For SWS subjects, who will receive MRI contrast material, additional exclusion criteria: 1. History of sensitivity to MRI contrast material; 2. History of renal disease that would preclude safe administration of MRI contrast material
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Wayne State University / Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
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Other studies related to the condition(s) this trial covers.