New combo may ease chemo nausea for breast cancer patients

NCT ID NCT03367572

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 17 times

Summary

This study tested whether adding prochlorperazine or olanzapine to standard anti-nausea medication (netupitant/palonosetron and dexamethasone) could better control nausea and vomiting caused by chemotherapy in breast cancer patients. Over 1,300 women who had not had chemotherapy before and were scheduled to receive certain drugs (doxorubicin, cyclophosphamide, or carboplatin) took part. The goal was to see if the extra drugs improved nausea ratings during the first two treatment cycles.

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Contacts and locations

Locations

  • Aurora NCORP

    Milwaukee, Wisconsin, 53226, United States

  • Cancer Research Consortium of West Michigan

    Grand Rapids, Michigan, 49503, United States

  • Cancer Research for the Ozarks NCORP

    Springfield, Missouri, 65804, United States

  • Columbus NCORP

    Columbus, Ohio, 43215, United States

  • Dayton Clinical Oncology Program

    Dayton, Ohio, 45459, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Geisinger Cancer Institute NCORP

    Danville, Pennsylvania, 17822, United States

  • Greenville NCORP

    Greenville, South Carolina, 29615, United States

  • Gulf South MU-NCORP

    New Orleans, Louisiana, 70112, United States

  • Gundersen Health System

    La Crosse, Wisconsin, 54601, United States

  • Hawaii MU NCORP

    Honolulu, Hawaii, 96813, United States

  • Health Partners Inc

    Minneapolis, Minnesota, 55454, United States

  • Michigan Cancer Research Consortium

    Ann Arbor, Michigan, 48106, United States

  • Nevada Cancer Research Foundation NCORP

    Las Vegas, Nevada, 89106, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • Southeast Clinical Oncology Research Program

    Winston-Salem, North Carolina, 27104, United States

  • University of Rochester NCORP Research Base

    Rochester, New York, 14642, United States

  • Upstate Carolina NCORP

    Spartanburg, South Carolina, 29303, United States

Conditions

Explore the condition pages connected to this study.