New hope for Hard-to-Treat breast cancer: targeted radiation plus hormone drugs enter human testing
NCT ID NCT05870579
First seen May 03, 2026 · Last updated May 16, 2026 · Updated 4 times
Summary
This early-phase study tests a new combination treatment for people with a certain type of advanced breast cancer (ER+, HER2-, GRPR+) that has stopped responding to standard hormone therapy. The treatment adds a targeted radiation drug ([177Lu]Lu-NeoB) to two existing hormone-blocking drugs (ribociclib and fulvestrant). The main goal is to find a safe dose and check for side effects in about 48 adults.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hoag Memorial Hospital Presbyterian
RECRUITINGNewport Beach, California, 92663, United States
Contact Email: •••••@•••••
Contact
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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Novartis Investigative Site
RECRUITINGGuangzhou, 510060, China
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Novartis Investigative Site
RECRUITINGShanghai, 200032, China
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Novartis Investigative Site
RECRUITINGTianjin, 300300, China
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Novartis Investigative Site
RECRUITINGSaint-Cloud, Hauts De Seine, 92210, France
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Novartis Investigative Site
RECRUITINGBordeaux, 33076, France
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Novartis Investigative Site
RECRUITINGClermont-Ferrand, 63011, France
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Novartis Investigative Site
RECRUITINGSaint-Herblain, 44805, France
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Novartis Investigative Site
RECRUITINGStrasbourg, F 67085, France
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Novartis Investigative Site
RECRUITINGCologne, North Rhine-Westphalia, 50937, Germany
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Novartis Investigative Site
RECRUITINGErlangen, 91054, Germany
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Novartis Investigative Site
RECRUITINGEssen, 45147, Germany
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Novartis Investigative Site
RECRUITINGMünchen, 80377, Germany
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Novartis Investigative Site
RECRUITINGGliwice, 44 101, Poland
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Novartis Investigative Site
RECRUITINGPorto, 4200-072, Portugal
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Novartis Investigative Site
RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Novartis Investigative Site
RECRUITINGBarcelona, 08035, Spain
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Novartis Investigative Site
RECRUITINGBarcelona, 08036, Spain
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Novartis Investigative Site
RECRUITINGMadrid, 28034, Spain
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Novartis Investigative Site
RECRUITINGMadrid, 28040, Spain
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UCLA Jonsson Comp Cancer Center
RECRUITINGLos Angeles, California, 90095, United States
Contact
Contact Email: •••••@•••••
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University of Kansas Medical Center
RECRUITINGWestwood, Kansas, 66205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Utah Intermountain Medical Center
RECRUITINGMurray, Utah, 84107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Conditions
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