Major trial tests best way to stop silent stroke threat

NCT ID NCT02089217

Completed Prevention Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

Summary

This large study aimed to find the best way to prevent strokes in people who have a major blockage in their neck (carotid) artery but have not yet had stroke symptoms. Over 2,400 participants were randomly assigned to receive either intensive medication alone, medication plus a surgical procedure to clean out the artery, or medication plus a less invasive procedure to place a stent. Everyone received strong medical management of risk factors like high blood pressure and cholesterol for four years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abrazo Arizona Heart Hospital

Phoenix, Arizona, 85016, United States
Atlanta VA Medical Center

Atlanta, Georgia, 30033, United States
Banner University Medical Center

Phoenix, Arizona, 85006, United States
Banner University Medical Center

Tucson, Arizona, 85724, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Baptist Memorial Hospital

Memphis, Tennessee, 38017, United States
Berks Cardiologists / St. Joseph's Medical Center

Wyomissing, Pennsylvania, 19610, United States
Beth Israel Deaconess Medical Center (BIDMC)

Boston, Massachusetts, 02215, United States
CHU de Québec/ Hôpital de l'Enfant-Jésus

Québec, Quebec, G1J1Z4, Canada
CVA Heart Institute

Kingsport, Tennessee, 37660, United States
Cardiac and Vascular Research Center of Northern Michigan/McLaren Northern Michigan

Petoskey, Michigan, 49770, United States
Cardiothoracic and Vascular Surgeons

Austin, Texas, 78756, United States
Cardiovascular Institute of Northwest Florida

Panama City, Florida, 32401, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Central Arkansas Veteran's Healthcare System

Little Rock, Arkansas, 72143, United States
Coastal Carolina Surgical Associates PA

Wilmington, North Carolina, 28401, United States
Columbia University Medical Center

New York, New York, 10032, United States
Cooper University

Camden, New Jersey, 08103, United States
Cox Medical Center

Springfield, Missouri, 65807, United States
Crouse Hospital

Syracuse, New York, 13210, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Deaconess Heart Group

Newburgh, Indiana, 47630, United States
Doylestown Hospital

Doylestown, Pennsylvania, 18901, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University

Atlanta, Georgia, 30322, United States
Fiona Stanley Hospital

Perth, Australia
First Coast Cardiovascular Institute

Jacksonville, Florida, 32216, United States
Franciscan St. Francis Health

Indianapolis, Indiana, 46237, United States
George E. Wahlen Department of Veterans Affairs Medical Center

Salt Lake City, Utah, 84148, United States
Good Samaritan Hospital

Cincinnati, Ohio, 45220, United States
Gundersen Clinic, Ltd

La Crosse, Wisconsin, 54601, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center

Jerusalem, 91120, Israel
Hartford Hospital

Hartford, Connecticut, 06102, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
HonorHealth Scottsdale Osborn Medical Center

Scottsdale, Arizona, 85251, United States
Hospital Clinic Barcelona

Barcelona, Spain
Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Huntsville Hospital/ Heart Center Research Alabama

Huntsville, Alabama, 35801, United States
Inova Fairfax Health Care

Falls Church, Virginia, 22042, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Jobst Vascular Institute/University of Toledo

Toledo, Ohio, 43606, United States
John Cochran VA Medical Center

St Louis, Missouri, 63106, United States
Johns Hopkins Medical Institution

Baltimore, Maryland, 21224, United States
Kaiser Permanente

San Diego, California, 92116, United States
Kaiser Permanente Los Angeles

Los Angeles, California, 90027, United States
Kaiser Permanente Northern California

San Francisco, California, 94115, United States
Keck Medical Center of University of Southern California

Los Angeles, California, 90033, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Lehigh Valley Hospital - Network Office of Research

Allentown, Pennsylvania, 18103, United States
Louis Stokes Cleveland VA Medical Center

Cleveland, Ohio, 44106, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Lyerly Neurosurgery

Jacksonville, Florida, 32207, United States
Maine Medical Center

Portland, Maine, 04102, United States
Massachusetts General Hospital

Boston, Massachusetts, 02144, United States
Mayo Clinic

Jacksonville, Florida, 32224, United States
Mayo Clinic Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Medstar/Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Memorial Hermann Texas Medical Center

Houston, Texas, 77030, United States
Mercy Health Riverside

Rockford, Illinois, 61114, United States
Mercy Health St. Vincent Medical Center

Toledo, Ohio, 43608, United States
Mercy Hospital

St Louis, Missouri, 63141, United States
Mercy Medical Research Institute

Springfield, Missouri, 65807, United States
Miami Cardiac and Vascular Institute at Baptist Hospital of Miami

Miami, Florida, 33176, United States
Michigan Vascular Center/McLaren- Flint

Flint, Michigan, 48532, United States
Minneapolis Clinic of Neurology, Ltd./North Memorial Medical Center

Golden Valley, Minnesota, 55422, United States
Mission Cardiovascular Research

Fremont, California, 94538, United States
Mission Cardiovascular Research Institute

Fremont, California, 94538, United States
Morton Plant Hospital

Clearwater, Florida, 33756, United States
Mount Sinai Hospital New York

New York, New York, 10029, United States
Mount Sinai Medical Center of Florida

Miami Beach, Florida, 33140, United States
North Carolina Heart & Vascular Research

Raleigh, North Carolina, 27607, United States
North Central Heart Institute

Sioux Falls, South Dakota, 57108, United States
Northshore University

Evanston, Illinois, 60201, United States
Northwestern University

Evanston, Illinois, 60208, United States
Nova Scotia Health Authority

Halifax, Nova Scotia, B3H 3A7, Canada
Novant Health/Forsyth Medical Center

Winston-Salem, North Carolina, 27103, United States
Ochsner Health System

New Orleans, Louisiana, 70121, United States
Ohio State Medical Center

Columbia, Ohio, 43210, United States
OhioHealth Research Institute

Columbus, Ohio, 43214, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Overlake Hospital

Bellevue, Washington, 98004, United States
Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Pinnacle Health Cardiovascular Institute

Wormleysburg, Pennsylvania, 17043, United States
Prairie Heart/St. John's Hospital

Springfield, Illinois, 62701, United States
Providence Brain and Spine Institute

Portland, Oregon, 97225, United States
Providence Little Company of Mary Medical Center

Torrance, California, 90503, United States
Providence Sacred Heart Medical Center

Spokane, Washington, 99204, United States
Rabin Medical Center

Petah Tikva, Israel
Rambam Healthcare

Haifa, 3109601, Israel
SUNY Buffalo

Buffalo, New York, 14203, United States
San Francisco VA Medical Center

San Francisco, California, 94121, United States
Sanford Health

Fargo, North Dakota, 58104, United States
Seton Medical Center Austin

Austin, Texas, 78705, United States
Shaare-Zedek Medical Center

Jerusalem, Israel
Soroka University Medical Center

Beersheba, Israel
Soroka University Vascular Surgery

Beersheba, Israel
Southern Illinois Healthcare

Carbondale, Illinois, 62901, United States
Sparrow Clinical Research Institute

Lansing, Michigan, 48912, United States
St. Boniface Hospital

Winnipeg, Ontario, R2H 2A6, Canada
St. Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
St. Elizabeth's Medical Center

Boston, Massachusetts, 02135, United States
St. Francis Hospital

Roslyn, New York, 11576, United States
St. John Clinical Research Institute

Tulsa, Oklahoma, 74104, United States
St. Joseph's Hospital and Medical Center/Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
St. Joseph's Medical Center

Stockton, California, 95204, United States
St. Mary's Hospital Regional Medical Center

Grand Junction, Colorado, 81501, United States
St. Michael's Hospital

Toronto, Ontario, M5B 1W8, Canada
Stanford University Medical Center

Stanford, California, 94305, United States
Stony Brook University

Stony Brook, New York, 11794, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
Tallahassee Neurological Clinic

Tallahassee, Florida, 32308, United States
Tampa General/University of South Florida

Tampa, Florida, 33606, United States
Tennova Healthcare/ Turkey Creek Medical Center

Knoxville, Tennessee, 37934, United States
The Feinstein Institute of Medical Research/Northwell Health

Manhasset, New York, 11030, United States
The Miriam Hospital

Providence, Rhode Island, 02906, United States
The University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
The University of Chicago Medical Center

Chicago, Illinois, 60637, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Trinity Health/Michigan Heart

Ypsilanti, Michigan, 48197, United States
Tulane University Heart and Vascular

New Orleans, Louisiana, 70112, United States
UC San Diego Health

La Jolla, California, 92037, United States
UF Jacksonville

Jacksonville, Florida, 32209, United States
UPMC Altoona

Altoona, Pennsylvania, 16601, United States
UPMC Hamot

Erie, Pennsylvania, 16550, United States
UPMC Presbyterian University Hospital

Pittsburgh, Pennsylvania, 15213, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of California Irvine

Irvine, California, 92868, United States
University of California Los Angeles (UCLA)

Los Angeles, California, 90095, United States
University of California San Diego

San Diego, California, 92103, United States
University of California San Francisco

San Francisco, California, 94115, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Florida Health at Shands

Gainesville, Florida, 32610, United States
University of Iowa Hospitals & Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Kentucky Hospital

Lexington, Kentucky, 40536, United States
University of Louisville Hospital

Louisville, Kentucky, 40202, United States
University of Maryland VA

Baltimore, Maryland, 21201, United States
University of Massachusetts Memorial Hospital

Worcester, Massachusetts, 01605, United States
University of Miami Hospital

Miami, Florida, 33136, United States
University of Michigan Hospital and Health Systems

Ann Arbor, Michigan, 48109, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75235, United States
University of Utah Hospitals and Clinics

Salt Lake City, Utah, 84132, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States
University of Washington Medicine-Harborview Medical Center

Seattle, Washington, 98104, United States
University of Wisconsin Hospitals & Clinics

Madison, Wisconsin, 53792, United States
VA Ann Arbor Healthcare System

Ann Arbor, Michigan, 48105, United States
VA Palo Alto Health Care System

Palo Alto, California, 94304, United States
VA Pittsburgh Healthcare

Pittsburgh, Pennsylvania, 15240, United States
VA Puget Sound Health Care System

Seattle, Washington, 98108, United States
Valley Baptist Medical Center

Harlingen, Texas, 78551, United States
Vancouver General Hospital

Vancouver, British Columbia, V5Z 1M9, Canada
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Weill Cornell Medical College

New York, New York, 10065, United States
West Virginia University

Morgantown, West Virginia, 26554, United States
White Oak Medical Center

Takoma Park, Maryland, 20912, United States
William Beaumont Hospital

Royal Oak, Michigan, 48073, United States
Winchester Medical Center

Winchester, Virginia, 22601, United States
Yale New Haven Hospital

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

CAROTID STENOSIS