New immune drug STK-012 takes on tough lung cancers

NCT ID NCT05098132

Recruiting now Disease control Sponsor: Synthekine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 5 times

Summary

This study tests a new drug called STK-012, which is designed to boost the immune system's ability to fight cancer. It is being tested alone or with standard treatments (pembrolizumab, pemetrexed, carboplatin) in people with advanced solid tumors, especially those with a type of lung cancer called non-squamous non-small cell lung cancer that has not been treated before. The trial has two phases: first to find the right dose and check safety, then to see if adding STK-012 to standard care improves response rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: STK-012 (an engineered immune protein) combined with pembrolizumab, pemetrexed, and carboplatin
What this could lead to: If successful, this could lead to a new treatment option for people with advanced non-small cell lung cancer that doesn't respond to current immunotherapies.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not prove effective or safe. Side effects from the immune system or chemotherapy are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

1ST LINE NSCLC ADVANCED SOLID TUMOR NON-SMALL CELL LUNG CANCER UNTREATED ADVANCED NSCLC

Contacts and locations

Locations

Baptist Memorial Hospital Cancer Center
ACTIVE_NOT_RECRUITING

Memphis, Tennessee, 38120, United States
Beaumont Hospital
RECRUITING

Dublin, 09, Ireland
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Beverly Hills Cancer Center
RECRUITING

Beverly Hills, California, 90211, United States
Caraps Medline, Ltd (JSC VIAN)
RECRUITING

Tbilisi, 0159, Georgia
Cedars Sinai
RECRUITING

Los Angeles, California, 90048, United States
Clinica Universidad de Navarra - Pamplona
RECRUITING

Pamplona, 31008, Spain
Columbia University Irving Medical Center
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke Cancer Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Georgetown University
RECRUITING

Washington D.C., District of Columbia, 20057, United States
HealthPartners Cancer Center at Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92663, United States
Hospital Quirón Barcelona
RECRUITING

Barcelona, 08023, Spain
Hospital Regional de Málaga
RECRUITING

Málaga, 29011, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Institute of Clinical Oncology (ICO)
RECRUITING

Tbilisi, 0159, Georgia
Israel Georgian Medical Research Clinic Healthycore
RECRUITING

Tbilisi, 0159, Georgia
LTD High Technology Hospital Medcenter
RECRUITING

Batumi, 6000, Georgia
MD Anderson
RECRUITING

Madrid, 28033, Spain
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Northwell Health
RECRUITING

Lake Success, New York, 11042, United States
Northwest Medical Specialties
ACTIVE_NOT_RECRUITING

Tacoma, Washington, 98405, United States
Oncology Consultants
RECRUITING

Houston, Texas, 77303, United States
Providence Cancer Institute
RECRUITING

Portland, Oregon, 97123, United States
Providence Medical Foundation
RECRUITING

Fullerton, California, 92835, United States
Renovatio Clinical
WITHDRAWN

El Paso, Texas, 79915, United States
Renovatio Clinical
WITHDRAWN

The Woodlands, Texas, 77380, United States
START Dublin
RECRUITING

Dublin, 07, Ireland
START Rioja
RECRUITING

Logroño, 26006, Spain
Sarah Cannon Research Institute - Nashville
ACTIVE_NOT_RECRUITING

Nashville, Tennessee, 37203, United States
St. James Hospital
RECRUITING

Dublin, 08, Ireland
The James Cancer Hospital and Solove Research Institute
RECRUITING

Columbus, Ohio, 43210, United States
UC San Diego Moores Cancer Center
ACTIVE_NOT_RECRUITING

La Jolla, California, 92093-0698, United States
UCLA Hematology/Oncology - Santa Monica
RECRUITING

Santa Monica, California, 90404, United States
UPMC Hillman Cancer Center
TERMINATED

Pittsburgh, Pennsylvania, 15232, United States
University Hospital Galway
RECRUITING

Galway, H91 YR71, Ireland
University Hospitals Cleveland
RECRUITING

Cleveland, Ohio, 44106, United States
University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85721, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yale New Haven Hospital, Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

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