New chemo cocktail before transplant may stop leukemia relapse

NCT ID NCT01885689

First seen Nov 16, 2025 · Last updated Apr 30, 2026 · Updated 25 times

Summary

This study tests whether giving two chemotherapy drugs (clofarabine and melphalan) before a donor stem cell transplant can prevent leukemia from returning in patients whose cancer is in remission. The approach aims to kill any remaining cancer cells and help the donor cells take hold. The trial includes 72 adults with acute leukemia, myelodysplastic syndrome, or chronic myelomonocytic leukemia.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

Conditions

Explore the condition pages connected to this study.