New combo before transplant aims to beat High-Risk leukemia

NCT ID NCT03494569

First seen Nov 10, 2025 · Last updated Jun 11, 2026 · Updated 29 times

Summary

This study is for people with high-risk acute leukemia or myelodysplastic syndrome (MDS). It tests a new way to prepare the body for a donor stem cell transplant by combining targeted radiation (TMLI) with two chemotherapy drugs. The goal is to find the safest dose that kills cancer cells while allowing the donor cells to grow. The study is currently on hold.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

Conditions

Explore the condition pages connected to this study.