New drug combo aims to boost stem cell harvest for myeloma patients

NCT ID NCT05561751

Completed Disease control Sponsor: GPCR Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests whether a new drug called GPC-100, combined with propranolol and with or without G-CSF, can effectively mobilize stem cells in people with multiple myeloma who are preparing for an autologous stem cell transplant. The goal is to see if enough stem cells can be collected in just two sessions. The trial enrolled 30 adults who were eligible for transplant and had achieved at least a partial response to prior therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GPC-100 (burixafor) combined with propranolol, with or without G-CSF
What this could lead to: If successful, this could improve stem cell collection for multiple myeloma patients undergoing transplant, making the process more efficient and reducing the need for additional sessions.
What could go wrong: This is a small, early-phase trial with only 30 participants, so results may not apply to all patients. The combination may not work better than current methods, and side effects from the drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

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Locations

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center

New York, New York, 10021, United States
Indiana Blood and Marrow Transplantation

Indianapolis, Indiana, 46077, United States
John Theurer Cancer Center At Hackensack UMC

Hackensack, New Jersey, 07601, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
University of California, San Diego (UCSD) - Moores Cancer Center

La Jolla, California, 92037, United States
University of Florida (UF) - Shands Cancer Center

Gainesville, Florida, 32608, United States
University of Massachusetts

Worcester, Massachusetts, 01655, United States
Virginia Commonwealth University - Massey Cancer Center

Richmond, Virginia, 23284, United States

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