Genetic test guides statin use to prevent heart attacks
NCT ID NCT06820086
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether giving a daily statin (rosuvastatin 20mg) to healthy people with a high genetic risk for heart disease can prevent major cardiovascular events like heart attacks and strokes. Over 2,700 men and women aged 45-80 with top 20% genetic risk scores are being followed for five years. The goal is to see if this targeted prevention approach works better and is more cost-effective than standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rosuvastatin 20mg
What this could lead to
If successful, this could show that using genetic risk scores to guide statin therapy is an effective and cost-saving way to prevent heart attacks and strokes.
What could go wrong
This is a Phase 4 trial, but it's still early in terms of real-world implementation. The results may not apply to all populations, and statins can have side effects like muscle pain or liver issues.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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North Estonia Medical Centre
Tallinn, Harju, Estonia
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Tartu University Hospital
Tartu, Tartu, Estonia