New drug combo trial targets 'Undruggable' cancer mutation

NCT ID NCT04185883

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

Summary

This early-stage trial is testing the safety and effectiveness of a drug called sotorasib, both by itself and combined with other cancer therapies. It is for adults with advanced solid tumors that have a specific genetic change known as the KRAS p.G12C mutation. The main goal is to find out what side effects occur and what doses are safe for patients.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Aichi Cancer Center

Nagoya, Aichi-ken, 464-8681, Japan
Arizona Oncology Associates Professional Corporation

Tucson, Arizona, 85711, United States
Asan Medical Center

Seoul, 138-736, South Korea
Avera Cancer Institute

Sioux Falls, South Dakota, 57108, United States
Azienda Ospedaliero Universitaria Pisana

Pisa, 56126, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
CHU de Quebec Hopital de l Enfant Jesus

Québec, Quebec, G1J 1Z4, Canada
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata

Verona, 37126, Italy
Charite Universitaetsmedizin Berlin, Campus Virchow

Berlin, 13353, Germany
City of Hope National Medical Center

Duarte, California, 91010, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center

New York, New York, 10032, United States
Duke University

Durham, North Carolina, 27710, United States
Emory University

Atlanta, Georgia, 30322, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
GenesisCare -North Shore Oncology

St Leonards, New South Wales, 2065, Australia
Gibbs Cancer Center and Research Institute - Spartanburg

Spartanburg, South Carolina, 29303, United States
Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion)

Detroit, Michigan, 48202, United States
Hospital Clinic i Provincial de Barcelona

Barcelona, Catalonia, 08036, Spain
Hospital Universitari Vall d Hebron

Barcelona, Catalonia, 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Icon Cancer Care South Brisbane

South Brisbane, Queensland, 4101, Australia
Indiana University

Indianapolis, Indiana, 46202, United States
Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals

L'Hospitalet de Llobregat, Catalonia, 08908, Spain
Johns Hopkins University

Baltimore, Maryland, 21224, United States
Landeskrankenhaus Salzburg

Salzburg, 5020, Austria
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

Taoyuan District, 33305, Taiwan
Loma Linda University Cancer Center

Loma Linda, California, 92354, United States
Mary Crowley Cancer Research

Dallas, Texas, 75230, United States
Medizinische Universitaet Graz

Graz, 8036, Austria
Memorial Cancer Institute

Pembroke Pines, Florida, 33028, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
National Cancer Center Hospital East

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital

Tainan, 70403, Taiwan
National Taiwan University Hospital

Taipei, 10002, Taiwan
Nepean Cancer Centre

Kingswood, New South Wales, 2747, Australia
Northwest Cancer Specialists - Vancouver

Vancouver, Washington, 98684, United States
Northwest Medical Specialties, PLLC

Tacoma, Washington, 98405, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norwalk Hospital

Norwalk, Connecticut, 06856, United States
Oncology Consultants

Houston, Texas, 77030, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Rocky Mountain Cancer Centers Denver Midtown

Denver, Colorado, 80218, United States
Roswell Park Cancer Institute

Buffalo, New York, 32224, United States
Sarah Cannon Research Institute

Denver, Colorado, 80218, United States
Sarah Cannon Research Institute UK

London, W1G 6AD, United Kingdom
Seoul National University Hospital

Seoul, 03080, South Korea
St John of God Healthcare

Subiaco, Western Australia, 6008, Australia
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Texas Oncology Central-South

Austin, Texas, 78705, United States
Texas Oncology Northeast Texas

Tyler, Texas, 75702, United States
The Cancer Institute Hospital of Japanese Foundation for Cancer Research

Koto-ku, Tokyo, 135-8550, Japan
The Catholic University of Korea Seoul St Marys Hospital

Seoul, 06591, South Korea
The Queen Elizabeth Hospital

Woodville South, South Australia, 5011, Australia
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
US Oncology Research Investigational Products Center

The Woodlands, Texas, 77380, United States
United States Oncology Regulatory Affairs Corporate Office

Nashville, Tennessee, 37203, United States
Universitaetsklinikum Dresden

Dresden, 01307, Germany
Universitaetsklinikum Essen

Essen, 45147, Germany
Universitair Medisch Centrum Utrecht

Utrecht, 3584 CX, Netherlands
Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium
Universitatsklinikum Koln

Cologne, 50937, Germany
Universite Catholique de Louvain Cliniques Universitaires Saint Luc

Brussels, 1200, Belgium
University of California Davis Medical Center

Sacramento, California, 95817, United States
University of California Los Angeles

Santa Monica, California, 90404, United States
University of California San Diego Moores Cancer Center

La Jolla, California, 92093, United States
University of California San Francisco Mission Bay Campus

San Francisco, California, 94115, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45267, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Michigan

Ann Arbor, Michigan, 48109-5912, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19111, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of Southern California, Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22903, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Virginia Cancer Specialists, PC

Fairfax, Virginia, 22031, United States
Washington University

St Louis, Missouri, 63110-1093, United States
Yale New Haven Hospital

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED SOLID TUMORS KIRSTEN RAT SARCOMA (KRAS) PG12C MUTATION