New combo before surgery shows promise for KRAS lung cancer
NCT ID NCT05118854
First seen Nov 01, 2025 · Last updated May 19, 2026 · Updated 28 times
Summary
This study tests whether giving a targeted drug (sotorasib) together with standard chemotherapy before surgery can shrink tumors more effectively in people with a specific genetic mutation (KRAS G12C) in non-squamous non-small cell lung cancer. About 27 adults with stage IIA to IIIB lung cancer that can be surgically removed will receive the combination for 4 cycles, then have surgery. The main goal is to see if the tumor shows a major response in the removed tissue.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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