New drug shows promise for deadly lung condition

NCT ID NCT04896008

Completed Disease control Sponsor: Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding the drug sotatercept to standard treatments could help people with severe pulmonary arterial hypertension (PAH), a life-threatening lung disease. It involved 173 participants with advanced PAH who were at high risk of death. Researchers compared sotatercept to a placebo, looking at whether it could delay serious events like death, lung transplant, or hospitalization.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

AdventHealth Medical Group Advanced Lung Disease ( Site 1058)

Orlando, Florida, 32804, United States
Arizona Pulmonary Specialists ( Site 1010)

Phoenix, Arizona, 85013, United States
Brigham and Women's Hospital ( Site 1014)

Boston, Massachusetts, 02115, United States
CHRU Lille ( Site 1306)

Lille, Nord, 59037, France
CHU Bicêtre ( Site 1304)

Le Kremlin-Bicêtre, Val-de-Marne, 94275, France
CHU de Nancy - Hôpital de Brabois Adultes ( Site 1308)

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511, France
CHU de Poitiers ( Site 1316)

Poitiers, Vienne, 86021, France
Centre Hospitalier Universitaire de Toulouse. ( Site 1315)

Toulouse, Haute-Garonne, 31059, France
David Geffen School of Medicine at UCLA ( Site 1068)

Los Angeles, California, 90095, United States
Duke University Medical Center ( Site 1026)

Durham, North Carolina, 27713, United States
Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 2504)

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario 12 de Octubre ( Site 1603)

Madrid, 28041, Spain
Hôpital Erasme ( Site 1402)

Anderlecht, Bruxelles-Capitale, Region de, 1070, Belgium
Hôpital Louis Pradel ( Site 1317)

Bron, Rhone, 69500, France
Hôpitaux Universitaires de Strasbourg ( Site 1307)

Strasbourg, Bas-Rhin, 67000, France
Imperial College Healthcare NHS Trust ( Site 1203)

London, London, City of, W2 1NY, United Kingdom
Instituto Nacional De Cardiologia Dr. Ignacio Chavez ( Site 2503)

Mexico City, Mexico City, 14080, Mexico
Jewish General Hospital ( Site 2103)

Montreal, Quebec, H3T 1E2, Canada
John Hunter Hospital ( Site 1101)

New Lambton Heights, New South Wales, 2305, Australia
Krankenhaus Neuwittelsbach ( Site 1510)

München, Bavaria, 80639, Germany
La Sapienza-Università di Roma-Policlinico Umberto I ( Site 2402)

Roma, 161, Italy
Lady Davis Carmel Medical Center ( Site 1705)

Haifa, 34362, Israel
Mayo Clinic Jacksonville - PPDS ( Site 1045)

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin - Froedtert Hospital ( Site 1051)

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina - PPDS ( Site 1003)

Charleston, South Carolina, 29425, United States
Medizinische Hochschule Hannover ( Site 1505)

Hanover, Lower Saxony, 30625, Germany
Northside Hospital ( Site 1073)

Atlanta, Georgia, 30342, United States
Ospedale S. Giuseppe Multimedica ( Site 2403)

Milan, Lombardy, 20123, Italy
Peter Lougheed Centre ( Site 2102)

Calgary, Alberta, T1Y 6J4, Canada
Royal Brompton Hospital ( Site 1206)

London, London, City of, SW3 6JY, United Kingdom
Royal Papworth Hospital ( Site 1208)

Cambridge, Cambridgeshire, CB23 3RE, United Kingdom
St Vincent's Hospital Sydney ( Site 1102)

Darlinghurst, New South Wales, 2010, Australia
Statcare Pulmonary Consultants - Knoxville ( Site 1031)

Knoxville, Tennessee, 37909, United States
The Cleveland Clinic Foundation. ( Site 1065)

Cleveland, Ohio, 44103-3736, United States
The George Washington University Medical Faculty Associates ( Site 1025)

Washington D.C., District of Columbia, 20037, United States
Thoraxklinik-Heidelberg gGmbH ( Site 1509)

Heidelberg, Baden-Wurttemberg, 69126, Germany
Tufts Medical Center - PPDS ( Site 1012)

Boston, Massachusetts, 02111, United States
UZ Leuven Campus Gasthuisberg ( Site 1401)

Leuven, Vlaams-Brabant, 3000, Belgium
Unidad de Investigación Clínica en Medicina, S.C ( Site 2505)

Monterrey, Nuevo León, 64718, Mexico
Uniklinik Köln ( Site 1511)

Cologne, North Rhine-Westphalia, 50937, Germany
Universitaetsklinikum Giessen und Marburg GmbH ( Site 1512)

Giessen, Hesse, 35392, Germany
University Of Iowa Hospitals and Clinics ( Site 1050)

Iowa City, Iowa, 52242, United States
University Of Texas Southwestern Medical Center ( Site 1038)

Dallas, Texas, 75390, United States
University of California Irvine ( Site 1086)

Orange, California, 92868-2994, United States
University of California San Diego Medical Center ( Site 1002)

San Diego, California, 92037, United States
University of California San Francisco ( Site 1019)

San Francisco, California, 94118, United States
University of Cincinnati Medical Center ( Site 1035)

Cincinnati, Ohio, 45267-0558, United States
University of Colorado Hospital ( Site 1013)

Aurora, Colorado, 80045, United States
University of Kansas Medical Center ( Site 1020)

Kansas City, Kansas, 66160, United States
University of Michigan ( Site 1011)

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center ( Site 1053)

Omaha, Nebraska, 68105, United States
University of New Mexico Health Sciences Center ( Site 1048)

Albuquerque, New Mexico, 87131, United States
University of Rochester Medical Center - PPDS ( Site 1039)

Rochester, New York, 14642-0001, United States
Universitätsklinikum Carl Gustav Carus an der TU Dresden. ( Site 1501)

Dresden, Saxony, 01307, Germany
Universitätsklinikum des Saarlandes ( Site 1513)

Homburg, Saarland, 66424, Germany
VU Medisch Centrum ( Site 2601)

Amsterdam, North Holland, 1081 HV, Netherlands
Washington University School of Medicine ( Site 1022)

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

PULMONARY ARTERIAL HYPERTENSION