Pancreatic cancer drug trial halted over safety issues

NCT ID NCT05525286

First seen Nov 17, 2025 · Last updated May 14, 2026 · Updated 26 times

Summary

This study tested a new drug called SOT102, alone or with standard chemotherapy, in 31 people with advanced pancreatic cancer. The goal was to find the safest dose and see if it helped shrink tumors. However, the trial was stopped early because of unexpected safety problems that reappeared even after changes were made.

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Contacts and locations

Locations

  • Cleveland Clinic Main Campus

    Cleveland, Ohio, 44195, United States

  • Hospital Universitario HM Sanchinarro

    Madrid, Spain

  • Institut Gustave Roussy

    Paris, France

  • Institut Jules Bordet

    Brussels, Belgium

  • Masarykův Onkologický Ústav

    Brno, Czechia

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, Belgium

  • VHIO - Vall d'Hebron Institut d'Oncologia

    Barcelona, Spain

  • Washington University School of Medicine in St. Louis

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.