New drug combo shows promise for tough thyroid cancer

NCT ID NCT02143726

First seen Feb 19, 2026 · Last updated May 13, 2026 · Updated 9 times

Summary

This study tested whether adding everolimus to the standard drug sorafenib helps people with a rare, advanced thyroid cancer that no longer responds to radioactive iodine. The trial included 35 adults with measurable tumors. Researchers measured how long the cancer stayed under control and whether tumors shrank, while also watching for side effects.

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Contacts and locations

Locations

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Sleepy Hollow

    Sleepy Hollow, New York, 10591, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • Mercy Health System

    Janesville, Wisconsin, 53547, United States

  • Nebraska Methodist Hospital

    Omaha, Nebraska, 68114, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Siouxland Regional Cancer Center

    Sioux City, Iowa, 51101, United States

  • Southeastern Medical Oncology Center-Clinton

    Clinton, North Carolina, 28328, United States

  • Southeastern Medical Oncology Center-Goldsboro

    Goldsboro, North Carolina, 27534, United States

  • Southeastern Medical Oncology Center-Jacksonville

    Jacksonville, North Carolina, 28546, United States

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • Wayne Memorial Hospital

    Goldsboro, North Carolina, 27534, United States

Conditions

Explore the condition pages connected to this study.