New hope for advanced cancer patients as experimental drug enters human trials

NCT ID NCT06736704

Recruiting now Disease control Sponsor: Pikavation Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new medicine, SNV4818, in about 320 adults with advanced solid tumors that have a specific genetic change (PIK3CA mutation) and have not responded to other treatments. The main goals are to check safety and find the best dose, either alone or with other cancer drugs. This is an early-stage trial, so it focuses on safety and dosing rather than proving a cure.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Linear Clinical Research
RECRUITING

Nedlands, Western Australia, 6009, Australia
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Scientia Clinical Research
RECRUITING

Randwick, New South Wales, 2031, Australia
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate
RECRUITING

Los Angeles, California, 90025, United States
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The University of Texas M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University-Sidney Kimmel Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University Health Network, Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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