New combo therapy for smokers with schizophrenia: early hints, big questions
NCT ID NCT06374290
First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 33 times
Summary
This small pilot study tested whether a combination of an injectable drug (naltrexone) and an oral drug (bupropion) is safe and feasible for helping people with schizophrenia quit smoking. Only 2 participants were enrolled before the study was terminated. The goal was to see if the treatment could reduce cigarette cravings and smoking without worsening schizophrenia symptoms.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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The University of Texas health Science Center at Houston
Houston, Texas, 77030, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Naltrexone (extended-release injection) and bupropion (oral tablet)
What this could lead to
If it works, this could point toward a safe way to help people with schizophrenia quit smoking.
What could go wrong
This is a very early, tiny pilot study (only 2 participants) that was terminated. Results may not apply to larger groups, and side effects are not well understood.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.