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New study aims to stop severe reactions to cancer infusion therapy

NCT ID NCT05663866

Ongoing Prevention Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This phase 2 study tests whether giving dexamethasone, montelukast, or methotrexate before an amivantamab infusion can reduce or prevent infusion-related reactions in people with a type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The study enrolled 68 participants who had previously been treated with osimertinib. The goal is to make the infusion safer and more tolerable.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

  • Asan Medical Center

    Seoul, 05505, South Korea

  • CHU Rouen Hopital Charles Nicolle

    Rouen, 76000, France

  • CHU de Brest - Hopital de la Cavale Blanche

    Brest, 29200, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Changhua Christian Hospital

    Changhua, 500, Taiwan

  • Chi-Mei Medical Center, Liouying

    Tainan, 73657, Taiwan

  • Chonnam National University Hwasun Hospital

    Jeollanam-do, 58128, South Korea

  • Chungbuk National University Hospital

    Cheongju-si, 28644, South Korea

  • Compassionate Cancer Care

    Fountain Valley, California, 92708, United States

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Hopital Cochin

    Paris, 75014, France

  • Hopital Europeen Georges-Pompidou

    Paris, 75015, France

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp Virgen de La Victoria

    Málaga, 29010, Spain

  • Hosp. Clinico Univ. Lozano Blesa

    Zaragoza, 50009, Spain

  • Hosp. Clinico Univ. de Santiago

    Santiago de Compostela, 15706, Spain

  • Hosp. Gral. Univ. Gregorio Maranon

    Madrid, 28007, Spain

  • Hosp. Gral. Univ. Valencia

    Valencia, 46014, Spain

  • Hosp. San Pedro de Alcantara

    Cáceres, 10003, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Quiron Dexeus

    Barcelona, 8028, Spain

  • Hosp. Univ. Son Espases

    Palma de Mallorca, 07120, Spain

  • Hosp. de Jerez de La Frontera

    Jerez de la Frontera, 11407, Spain

  • Hosp. de La Santa Creu I Sant Pau

    Barcelona, 08025, Spain

  • Inst. Cat. Doncologia-H Duran I Reynals

    L'Hospitalet de Llobregat, 08908, Spain

  • Inst. Valenciano de Oncologia

    Valencia, 46009, Spain

  • Kaohsiung Medical University Chung Ho Memorial Hospital

    Kaohsiung City, 80756, Taiwan

  • National Cancer Center

    Gyeonggi-do, 10408, South Korea

  • National Taiwan University Hospital

    Taipei, 10043, Taiwan

  • Nouvel Hopital Civil - CHU Strasbourg

    Strasbourg, 67091, France

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620, South Korea

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Medical University

    Taipei, 110, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • UW Medicine Valley Medical Center

    Renton, Washington, 98055, United States

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

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