New hope for advanced skin cancer: boosting immune system before surgery

NCT ID NCT06568172

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is testing if adding an immunotherapy drug (cemiplimab) before and after surgery works better than surgery alone for people with advanced, operable skin cancer. The goal is to see if this approach helps the body's immune system fight the cancer, reduces the chance of it coming back, and improves survival. About 420 participants with stage III or IV squamous cell skin cancer that can be surgically removed will be randomly assigned to receive either the new combination treatment or the current standard of care.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Allegheny General Hospital
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Pittsburgh, Pennsylvania, 15212, United States

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Alton Memorial Hospital
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Alton, Illinois, 62002, United States

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Atrium Health Cabarrus/LCI-Concord
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Concord, North Carolina, 28025, United States

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Atrium Health Cleveland/LCI-Cleveland
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Shelby, North Carolina, 28150, United States

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Atrium Health Pineville/LCI-Pineville
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Charlotte, North Carolina, 28210, United States

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Atrium Health Stanly/LCI-Albemarle
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Albemarle, North Carolina, 28002, United States

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Atrium Health Union/LCI-Union
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Monroe, North Carolina, 28112, United States

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Atrium Health University City/LCI-University
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Charlotte, North Carolina, 28262, United States

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Atrium Medical Center-Middletown Regional Hospital
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Franklin, Ohio, 45005-1066, United States

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BCCA-Vancouver Cancer Centre
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Vancouver, British Columbia, V5Z 4E6, Canada

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Banner MD Anderson Cancer Center
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Gilbert, Arizona, 85234, United States

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Carolinas Medical Center/Levine Cancer Institute
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Charlotte, North Carolina, 28203, United States

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Case Western Reserve University
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Cleveland, Ohio, 44106, United States

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Cedars Sinai Medical Center
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Los Angeles, California, 90048, United States

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Chris O'Brien Lifehouse
SUSPENDED

Camperdown, New South Wales, 2050, Australia
Christiana Care Health System-Concord Health Center
RECRUITING

Chadds Ford, Pennsylvania, 19317, United States

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City of Hope Antelope Valley
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Lancaster, California, 93534, United States

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City of Hope Comprehensive Cancer Center
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Duarte, California, 91010, United States

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City of Hope South Pasadena
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South Pasadena, California, 91030, United States

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City of Hope Upland
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Upland, California, 91786, United States

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City of Hope at Irvine Lennar
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Irvine, California, 92618, United States

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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
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Grand Rapids, Michigan, 49503, United States

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Dartmouth Cancer Center - North
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Saint Johnsbury, Vermont, 05819, United States

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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
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Lebanon, New Hampshire, 03756, United States

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Drexel Town Square Health Center
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Oak Creek, Wisconsin, 53154, United States

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Duke Cancer Center Raleigh
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Raleigh, North Carolina, 27609, United States

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Duke University Medical Center
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Durham, North Carolina, 27710, United States

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Emory University Hospital Midtown
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Atlanta, Georgia, 30308, United States

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Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, 30322, United States

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First Physicians Group - Silverstein Institute at Floyd Street
RECRUITING

Sarasota, Florida, 34239, United States

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Florida Cancer Specialists - Sarasota
RECRUITING

Sarasota, Florida, 34232, United States

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Florida Cancer Specialists - Sarasota Downtown
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Sarasota, Florida, 34236, United States

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Florida Cancer Specialists - Venice Island
RECRUITING

Venice, Florida, 34285, United States

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Florida Cancer Specialists - Venice Pinebrook
RECRUITING

Venice, Florida, 34275, United States

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Forbes Hospital
RECRUITING

Monroeville, Pennsylvania, 15146, United States

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Fox Chase Cancer Center
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Philadelphia, Pennsylvania, 19111, United States

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Franciscan Health Indianapolis
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Indianapolis, Indiana, 46237, United States

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Froedtert Menomonee Falls Hospital
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Menomonee Falls, Wisconsin, 53051, United States

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Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States

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Goshen Center for Cancer Care
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Goshen, Indiana, 46526, United States

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Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

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Heartland Oncology and Hematology LLP
SUSPENDED

Council Bluffs, Iowa, 51503, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States

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Henry Ford Hospital
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Detroit, Michigan, 48202, United States

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Huntsman Cancer Institute/University of Utah
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Salt Lake City, Utah, 84112, United States

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IU Health North Hospital
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Carmel, Indiana, 46032, United States

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Indiana University/Melvin and Bren Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States

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Inova Schar Cancer Institute
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Fairfax, Virginia, 22031, United States

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Kaiser Permanente-Oakland
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Oakland, California, 94611, United States

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Kaiser Permanente-San Francisco
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San Francisco, California, 94115, United States

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Kaiser Permanente-South Sacramento
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Sacramento, California, 95823, United States

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Kaiser Permanente-Walnut Creek
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Walnut Creek, California, 94596, United States

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LSU Health Baton Rouge-North Clinic
RECRUITING

Baton Rouge, Louisiana, 70805, United States

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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

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Levine Cancer Institute-Gaston
RECRUITING

Gastonia, North Carolina, 28054, United States

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Levine Cancer Institute-Rock Hill
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Rock Hill, South Carolina, 29732, United States

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M D Anderson Cancer Center
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Houston, Texas, 77030, United States

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MD Anderson League City
RECRUITING

League City, Texas, 77573, United States

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MD Anderson West Houston
RECRUITING

Houston, Texas, 77079, United States

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MD Anderson in Sugar Land
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Sugar Land, Texas, 77478, United States

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MD Anderson in The Woodlands
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Conroe, Texas, 77384, United States

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MU Health - University Hospital/Ellis Fischel Cancer Center
RECRUITING

Columbia, Missouri, 65212, United States

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Marshfield Medical Center - Weston
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Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-Marshfield
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Marshfield, Wisconsin, 54449, United States

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Mayo Clinic Hospital in Arizona
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Phoenix, Arizona, 85054, United States

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Mayo Clinic in Florida
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Jacksonville, Florida, 32224-9980, United States

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Mayo Clinic in Rochester
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Rochester, Minnesota, 55905, United States

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Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States

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Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States

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Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States

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Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States

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Memorial Sloan Kettering Cancer Center
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New York, New York, 10065, United States

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Memorial Sloan Kettering Commack
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Commack, New York, 11725, United States

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Memorial Sloan Kettering Monmouth
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Middletown, New Jersey, 07748, United States

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Memorial Sloan Kettering Nassau
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Uniondale, New York, 11553, United States

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Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States

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Methodist Jennie Edmundson Hospital
SUSPENDED

Council Bluffs, Iowa, 51503, United States
MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States

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Miami Cancer Institute
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Miami, Florida, 33176, United States

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Miami Valley Cancer Care and Infusion
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Greenville, Ohio, 45331, United States

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Miami Valley Hospital North
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Dayton, Ohio, 45415, United States

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Miami Valley Hospital South
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Centerville, Ohio, 45459, United States

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Moffitt Cancer Center
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Tampa, Florida, 33612, United States

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Moffitt Cancer Center - McKinley Campus
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Tampa, Florida, 33612, United States

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Moffitt Cancer Center-International Plaza
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Tampa, Florida, 33607, United States

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Montefiore Medical Center - Moses Campus
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The Bronx, New York, 10467, United States

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Montefiore Medical Center-Einstein Campus
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The Bronx, New York, 10461, United States

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Montefiore Medical Center-Weiler Hospital
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The Bronx, New York, 10461, United States

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NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States

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Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
RECRUITING

Omaha, Nebraska, 68114, United States

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Nebraska Medicine-Bellevue
RECRUITING

Bellevue, Nebraska, 68123, United States

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Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States

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Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States

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Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States

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Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States

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Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States

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Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

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Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

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Odette Cancer Centre- Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada

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Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

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Our Lady of the Lake Physician Group
RECRUITING

Baton Rouge, Louisiana, 70808, United States

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Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States

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Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia

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Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia

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Rock Hill Radiation Therapy Center
RECRUITING

Rock Hill, South Carolina, 29730, United States

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Rush MD Anderson Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States

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SUNY Upstate Medical Center-Community Campus
RECRUITING

Syracuse, New York, 13215, United States

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Saint Vincent Hospital
RECRUITING

Erie, Pennsylvania, 16544, United States

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Sarasota Memorial Health Care Center at University Parkway
RECRUITING

Sarasota, Florida, 34243, United States

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Sarasota Memorial Hospital
RECRUITING

Sarasota, Florida, 34239, United States

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Sarasota Memorial Hospital-Venice
RECRUITING

N. Venice, Florida, 34275, United States

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Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

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Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

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Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

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Smilow Cancer Hospital Care Center - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States

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Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States

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Smilow Cancer Hospital Care Center at Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States

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Smilow Cancer Hospital Care Center-Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States

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Smilow Cancer Hospital-Waterbury Care Center
RECRUITING

Waterbury, Connecticut, 06708, United States

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Stanford Cancer Institute Palo Alto
RECRUITING

Palo Alto, California, 94304, United States

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State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States

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Stony Brook University Medical Center
SUSPENDED

Stony Brook, New York, 11794, United States
The Angeles Clinic and Research Institute - West Los Angeles Office
RECRUITING

Los Angeles, California, 90025, United States

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The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States

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Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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Torrance Memorial Physician Network - Cancer Care
RECRUITING

Torrance, California, 90505, United States

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Tower Cancer Research Foundation
RECRUITING

Beverly Hills, California, 90211, United States

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UC San Diego Health System - Encinitas
RECRUITING

Encinitas, California, 92024, United States

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UC San Diego Medical Center - Hillcrest
RECRUITING

San Diego, California, 92103, United States

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UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

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UH Seidman Cancer Center at Lake Health Mentor Campus
RECRUITING

Mentor, Ohio, 44060, United States

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UH Seidman Cancer Center at UH Avon Health Center
RECRUITING

Avon, Ohio, 44011, United States

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UHHS-Chagrin Highlands Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States

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UM Sylvester Comprehensive Cancer Center at Aventura
RECRUITING

Aventura, Florida, 33180, United States

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UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States

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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

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UM Sylvester Comprehensive Cancer Center at Doral
RECRUITING

Doral, Florida, 33166, United States

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UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States

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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States

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UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

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UPMC-Johnstown/John P. Murtha Regional Cancer Center
RECRUITING

Johnstown, Pennsylvania, 15901, United States

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USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

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UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States

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UT Southwestern Simmons Cancer Center - RedBird
RECRUITING

Dallas, Texas, 75237, United States

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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

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UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

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University Health Network-Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States

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University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States

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University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States

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University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

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University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

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University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States

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University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States

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University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States

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University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States

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University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States

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University of Kansas Hospital-Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States

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University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States

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University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States

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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

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University of Michigan - Brighton Center for Specialty Care
RECRUITING

Brighton, Michigan, 48116, United States

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University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States

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University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States

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University of Minnesota/Masonic Cancer Center
RECRUITING

Minneapolis, Minnesota, 55455, United States

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University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

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University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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University of Rochester
RECRUITING

Rochester, New York, 14642, United States

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University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

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University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States

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University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States

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University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

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UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

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Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States

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VCU Massey Comprehensive Cancer Center
WITHDRAWN

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States

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Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

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Wexford Health and Wellness Pavilion
RECRUITING

Wexford, Pennsylvania, 15090, United States

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William S Middleton VA Medical Center
RECRUITING

Madison, Wisconsin, 53705, United States

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Contact Phone: •••-•••-••••
Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

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Wollongong Hospital
RECRUITING

Wollongong, New South Wales, 2500, Australia

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Contact Phone: •••-•••-••••
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.