Can chemo before surgery save faces in sinus cancer fight?

NCT ID NCT03493425

Recruiting now Disease control Sponsor: ECOG-ACRIN Cancer Research Group Source: ClinicalTrials.gov ↗

Summary

This study is testing whether giving chemotherapy before surgery helps preserve important facial structures like the eye socket and skull base in patients with advanced nasal and sinus cancer. It compares two approaches: one group gets surgery followed by radiation, while the other gets chemotherapy first, then surgery and radiation. The main goal is to see if the chemotherapy-first approach allows surgeons to remove less healthy tissue while still controlling the cancer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Allegiance Health
RECRUITING

Jackson, Michigan, 49201, United States

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Ascension Via Christi - Pittsburg
ACTIVE_NOT_RECRUITING

Pittsburg, Kansas, 66762, United States
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States

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Benefis Healthcare- Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Bozeman Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States

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Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

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Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

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Carle on Vermilion
RECRUITING

Danville, Illinois, 61832, United States

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Central Care Cancer Center - Bolivar
RECRUITING

Bolivar, Missouri, 65613, United States

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Central Care Cancer Center - Garden City
RECRUITING

Garden City, Kansas, 67846, United States

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Central Care Cancer Center - Great Bend
RECRUITING

Great Bend, Kansas, 67530, United States

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Community Medical Hospital
RECRUITING

Missoula, Montana, 59804, United States

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CoxHealth South Hospital
RECRUITING

Springfield, Missouri, 65807, United States

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Delbert Day Cancer Institute at PCRMC
RECRUITING

Rolla, Missouri, 65401, United States

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Diagnostic and Treatment Center
RECRUITING

Weston, Wisconsin, 54476, United States

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Emory Proton Therapy Center
RECRUITING

Atlanta, Georgia, 30308, United States

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Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States

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Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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Freeman Health System
RECRUITING

Joplin, Missouri, 64804, United States

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Good Samaritan Regional Health Center
RECRUITING

Mount Vernon, Illinois, 62864, United States

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Great Falls Clinic
RECRUITING

Great Falls, Montana, 59405, United States

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Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States

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Henry Ford Cancer Institute-Downriver
RECRUITING

Brownstown, Michigan, 48183, United States

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Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

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Henry Ford Macomb Health Center - Shelby Township
RECRUITING

Shelby, Michigan, 48315, United States

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Henry Ford Macomb Hospital-Clinton Township
RECRUITING

Clinton Township, Michigan, 48038, United States

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Henry Ford Medical Center-Columbus
RECRUITING

Novi, Michigan, 48377, United States

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Henry Ford Medical Center-Fairlane
RECRUITING

Dearborn, Michigan, 48126, United States

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Henry Ford West Bloomfield Hospital
RECRUITING

West Bloomfield, Michigan, 48322, United States

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Idaho Urologic Institute-Meridian
RECRUITING

Meridian, Idaho, 83642, United States

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Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States

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Inova Schar Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States

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Iowa Lutheran Hospital
RECRUITING

Des Moines, Iowa, 50316, United States

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Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States

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Kalispell Regional Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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Lawrence Memorial Hospital
ACTIVE_NOT_RECRUITING

Lawrence, Kansas, 66044, United States
Lenox Hill Hospital
RECRUITING

New York, New York, 10021, United States

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Long Island Jewish Medical Center
RECRUITING

New Hyde Park, New York, 11040, United States

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Marshfield Clinic Stevens Point Center
RECRUITING

Stevens Point, Wisconsin, 54482, United States

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Marshfield Clinic-Minocqua Center
RECRUITING

Minocqua, Wisconsin, 54548, United States

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Marshfield Clinic-Wausau Center
SUSPENDED

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

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Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

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Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

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Massachusetts General Hospital Cancer Center
SUSPENDED

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin
ACTIVE_NOT_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical Oncology and Hematology Associates-Des Moines
RECRUITING

Des Moines, Iowa, 50309, United States

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Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States

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Mercy Clinic-Rolla-Cancer and Hematology
RECRUITING

Rolla, Missouri, 65401, United States

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Mercy Hospital Fort Smith
RECRUITING

Fort Smith, Arkansas, 72903, United States

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Mercy Hospital Joplin
RECRUITING

Joplin, Missouri, 64804, United States

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Mercy Hospital Oklahoma City
RECRUITING

Oklahoma City, Oklahoma, 73120, United States

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Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States

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Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States

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Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States

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Methodist West Hospital
RECRUITING

West Des Moines, Iowa, 50266-7700, United States

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Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

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Moffitt Cancer Center - McKinley Campus
RECRUITING

Tampa, Florida, 33612, United States

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Moffitt Cancer Center-International Plaza
RECRUITING

Tampa, Florida, 33607, United States

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Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States

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Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States

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Montefiore Medical Center-Weiler Hospital
RECRUITING

The Bronx, New York, 10461, United States

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Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States

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NorthShore University HealthSystem-Evanston Hospital
RECRUITING

Evanston, Illinois, 60201, United States

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NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING

Glenview, Illinois, 60026, United States

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NorthShore University HealthSystem-Highland Park Hospital
RECRUITING

Highland Park, Illinois, 60035, United States

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Northwell Health Imbert Cancer Center
RECRUITING

Bay Shore, New York, 11706, United States

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Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States

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Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Olathe Health Cancer Center
ACTIVE_NOT_RECRUITING

Olathe, Kansas, 66061, United States
Parkland Memorial Hospital
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75235, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States

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Rush - Copley Medical Center
RECRUITING

Aurora, Illinois, 60504, United States

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Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States

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Saint Alphonsus Cancer Care Center-Boise
RECRUITING

Boise, Idaho, 83706, United States

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Saint Alphonsus Cancer Care Center-Caldwell
RECRUITING

Caldwell, Idaho, 83605, United States

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Saint Alphonsus Medical Center-Nampa
RECRUITING

Nampa, Idaho, 83686, United States

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Saint Anthony Regional Hospital
RECRUITING

Carroll, Iowa, 51401, United States

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Saint Louis Cancer and Breast Institute-Ballwin
RECRUITING

Ballwin, Missouri, 63011, United States

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Salina Regional Health Center
ACTIVE_NOT_RECRUITING

Salina, Kansas, 67401, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

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Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

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Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

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Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

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Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

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Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

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Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

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Smilow Cancer Center/Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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Stanford Cancer Institute Palo Alto
RECRUITING

Palo Alto, California, 94304, United States

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The Carle Foundation Hospital
RECRUITING

Urbana, Illinois, 61801, United States

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The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States

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Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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UC San Diego Moores Cancer Center
WITHDRAWN

La Jolla, California, 92093, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
SUSPENDED

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States

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UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States

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UPMC Jameson
SUSPENDED

New Castle, Pennsylvania, 16105, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITING

Harrisburg, Pennsylvania, 17109, United States

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UPMC Washington Hospital Radiation Oncology
RECRUITING

Washington, Pennsylvania, 15301, United States

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UPMC-Heritage Valley Health System Beaver
RECRUITING

Beaver, Pennsylvania, 15009, United States

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UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States

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UPMC-Presbyterian Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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UPMC-Shadyside Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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UT Southwestern Clinical Center at Richardson/Plano
ACTIVE_NOT_RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern/Simmons Cancer Center-Dallas
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States

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University of Arizona Cancer Center-Orange Grove Campus
RECRUITING

Tucson, Arizona, 85704, United States

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University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

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Contact
University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

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University of Kansas Cancer Center
ACTIVE_NOT_RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - North
ACTIVE_NOT_RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital
ACTIVE_NOT_RECRUITING

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park
ACTIVE_NOT_RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus
ACTIVE_NOT_RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
ACTIVE_NOT_RECRUITING

Westwood, Kansas, 66205, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

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University of Michigan Comprehensive Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States

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University of Oklahoma Health Sciences Center
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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University of Rochester
RECRUITING

Rochester, New York, 14642, United States

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VA Palo Alto Health Care System
RECRUITING

Palo Alto, California, 94304, United States

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Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact

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Wayne State University/Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

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Weisberg Cancer Treatment Center
RECRUITING

Farmington Hills, Michigan, 48334, United States

Contact

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Welch Cancer Center
RECRUITING

Sheridan, Wyoming, 82801, United States

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Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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Conditions

Explore the condition pages connected to this study.

STAGE III NASAL CAVITY AND PARANASAL SINUS SQUAMOUS CELL CARCINOMA AJCC V6 AND V7 STAGE IVA NASAL CAVITY AND PARANASAL SINUS SQUAMOUS CELL CARCINOMA AJCC V7