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Cholesterol drug could boost bone growth for dental implants

NCT ID NCT07692620

Completed Disease control Sponsor: Maruwan Ali Alteer Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial investigates whether adding a simvastatin and platelet-rich fibrin (PRF) composite to a standard bone graft improves bone regeneration during dental implant surgery. The study enrolls adults aged 18–50 with a narrow jawbone (3–5 mm wide) who need an implant in the lower front jaw. Participants are randomly assigned to receive either a bone graft alone, a bone graft with PRF, or a bone graft with a simvastatin/PRF composite. The goal is to see which approach yields the best bone gain and implant stability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Simvastatin and Platelet-Rich Fibrin (PRF) composite
What this could lead to
If successful, this approach could improve bone regeneration and implant success in patients with insufficient jawbone width, reducing the need for more invasive grafting procedures.
What could go wrong
This is a small, early-stage trial with only 21 participants, so results may not apply broadly. The added benefits of simvastatin and PRF over standard bone grafting are uncertain, and there is a risk of infection, implant failure, or adverse reactions to the materials.

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Conditions

The condition(s) this trial relates to.

Tooth Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALVEOLAR RIDGE ATROPHY TOOTH LOSS

Contacts and locations

Locations

  • Faculty of Oral and Dental Surgery, Misr University for Science and Technology

    Cairo, Giza Governorate, Egypt

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