Veterans' liver hope: statin may stave off cirrhosis crisis

NCT ID NCT03654053

First seen Nov 16, 2025 · Last updated Jun 10, 2026 · Updated 21 times

Summary

This study tests whether simvastatin, a drug typically used for cholesterol, can reduce the risk of serious liver problems in veterans with early-stage cirrhosis (scarred but symptom-free liver). About 142 participants will receive either simvastatin or a placebo to see if it prevents complications like bleeding or fluid buildup. The research also looks at how genes affect the drug's safety and effectiveness.

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Contacts and locations

Locations

  • Brooklyn Campus of the VA NY Harbor Healthcare System, Brooklyn, NY

    Brooklyn, New York, 11209, United States

  • Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Philadelphia, Pennsylvania, 19104-4551, United States

  • Hunter Holmes McGuire VA Medical Center, Richmond, VA

    Richmond, Virginia, 23249, United States

  • James J. Peters VA Medical Center, Bronx, NY

    The Bronx, New York, 10468, United States

  • Michael E. DeBakey VA Medical Center, Houston, TX

    Houston, Texas, 77030, United States

  • Philadelphia MultiService Center, Philadelphia, PA

    Philadelphia, Pennsylvania, 19106, United States

  • Robley Rex VA Medical Center, Louisville, KY

    Louisville, Kentucky, 40206, United States

  • San Francisco VA Medical Center, San Francisco, CA

    San Francisco, California, 94121, United States

  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

    Boston, Massachusetts, 02130, United States

  • VA Connecticut Healthcare System West Haven Campus, West Haven, CT

    West Haven, Connecticut, 06516, United States

  • VA Puget Sound Health Care System Seattle Division, Seattle, WA

    Seattle, Washington, 98108, United States

Conditions

Explore the condition pages connected to this study.