Major Alzheimer's drug trial halted early

NCT ID NCT05026177

Terminated Disease control Sponsor: Cassava Sciences, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether a drug called simufilam could slow memory and thinking decline in people with mild-to-moderate Alzheimer's disease. About 1,125 participants took either the drug or a placebo pill twice daily for 76 weeks. The trial was terminated early, and researchers measured changes in memory tests, daily function, and brain health markers.

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Contacts and locations

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Locations

Accel Research Sites - NeuroStudies

Decatur, Georgia, 30030, United States
Accellacare Research of Winston-Salem

Winston-Salem, North Carolina, 27103, United States
ActivMed Practices & Research, LLC

Methuen, Massachusetts, 01844, United States
Advanced Memory Research Institute of NJ

Toms River, New Jersey, 08755, United States
Advocate Aurora Health

Park Ridge, Illinois, 60068, United States
Albany Medical Center

Albany, New York, 12208, United States
Alphab Global Research

Jupiter, Florida, 33458, United States
Alzheimer's Research & Treatment Center

Stuart, Florida, 34997, United States
Alzheimer's Research & Treatment Center

Wellington, Florida, 33414, United States
Arizona Neuroscience Research, LLC

Phoenix, Arizona, 85032, United States
Asan Medical Center

Seoul, Songpa-gu, 05505, South Korea
Banner Alzheimer's Institute

Phoenix, Arizona, 85006, United States
Banner Alzheimer's Institute - Tucson

Tucson, Arizona, 85718, United States
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Barbara Diaz Hernandez Md Research, Inc.

San Juan, 00926, Puerto Rico
Boston Center for Memory

Newton, Massachusetts, 02459, United States
Brain Matters Research Inc

Delray Beach, Florida, 33445, United States
Brain Matters Research Inc

Stuart, Florida, 34997, United States
Brainstorm Research

Miami, Florida, 33176, United States
California Research Insitute

Los Angeles, California, 90027, United States
Cedar Health Research

Irving, Texas, 75062, United States
Center for Cognitive Health - Portland

Portland, Oregon, 97225, United States
Centre Hospitalier Universitaire Dr-Georges-L.-Dumont (CHUDGLD)

Moncton, New Brunswick, E1C 2Z3, Canada
Chonnam National University Hospital

Gwangju, Dong-gu, 61469, South Korea
Clinical Endpoints

Scottsdale, Arizona, 85258, United States
Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

Orlando, Florida, 32801, United States
Clinical Research of Brandon, LLC

Brandon, Florida, 33511, United States
Columbus Memory Center, PC

Columbus, Georgia, 31909, United States
Conquest Research

Winter Park, Florida, 32789, United States
Djavad Mowafaghian Centre for Brain Health

Vancouver, British Columbia, V6T 1Z3, Canada
Gachon University Gil Hospital

Namdong-gu, Incheon, 21565, South Korea
Global Medical Institutes, LLC

Princeton, New Jersey, 08540, United States
Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States
HanYang University Hospital

Seongdong-gu, Seoul, 04763, South Korea
Hanyang University Guri Hospital

Guri-si, Gyeonggi-do, 11923, South Korea
Health Synergy Clinical Research

Okeechobee, Florida, 34972, United States
Healthy Brain Clinic

Long Beach, California, 90804, United States
Indago Research and Health Center, Inc.

Hialeah, Florida, 33012, United States
Inha University Medical Center

Incheon, Jung-go, 22332, South Korea
Inspira Clinical Research

San Juan, 00918, Puerto Rico
Instituto De Neurologia Dra. Ivonne Fraga

San Juan, Puerto Rico
Integrative Clinical Trials

Brooklyn, New York, 11229, United States
Intercoastal Medical Group - Sarasota

Sarasota, Florida, 34239, United States
JEM Research Institute

Atlantis, Florida, 33462, United States
K2 Medical Research

Maitland, Florida, 32751, United States
KCA Neurology, PLLC

Franklin, Tennessee, 37067, United States
Kawartha Centre - Redefining Healthy Aging

Peterborough, Ontario, K9H2P4, Canada
Keystone Clinical Studies, LLC

Plymouth Meeting, Pennsylvania, 19462, United States
Ki Health Partners, LLC

Stamford, Connecticut, 06905, United States
Korea University Anam Hospital

Seongbuk-gu, Seoul, 02841, South Korea
Kyungpook National University Chilgok Hospital

Daegu, North Gyeongsang Province, 61469, South Korea
MedVadis Research

Waltham, Massachusetts, 02451, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Mind Institute at Miami Jewish Health

Miami, Florida, 33137, United States
Neuro-Behavioral Clinical Research (NBCR)

North Canton, Ohio, 44720, United States
Neuro-Pain Medical Center

Fresno, California, 93710, United States
Neurological Associates of Albany

Albany, New York, 12208, United States
Neurology Center of New England

Foxborough, Massachusetts, 02035, United States
Neurology Center of North Orange County

Fullerton, California, 92835, United States
Neurology Consultants of Dallas, PA

Dallas, Texas, 75243, United States
Neurology Diagnostics

Dayton, Ohio, 45459, United States
North County Neurology Associates

Carlsbad, California, 92011, United States
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Nuvance Health Medical Practice CT, Inc. - Associated Neurologists, PC

Danbury, Connecticut, 06810, United States
OCT Research ULC DBA Okanagan Clinical Trials

Kelowna, British Columbia, V1Y 2Z9, Canada
Office of Donald S. Marks, M.D., P.C.

Plymouth, Massachusetts, 02360, United States
Ohio State University

Columbus, Ohio, 43210, United States
Ottawa Memory Clinic

Ottawa, Ontario, K1Z 1G3, Canada
Pacific Research Network, LLC

San Diego, California, 92103, United States
Parkinson's Disease and Movement Disorders Center of Boca Raton

Boca Raton, Florida, 33486, United States
Patient First MD

Middletown, New Jersey, 07748, United States
Quantum Laboratories

Deerfield Beach, Florida, 33442, United States
Recherches Neuro-Hippocampe Inc.

Ottawa, Ontario, K1Z 1G3, Canada
Richmond Behavioral Associates

Staten Island, New York, 10312, United States
SPRI Clinical Trials Brooklyn

Brooklyn, New York, 11235, United States
Santa Cruz Behavioral PSC

Bayamón, 00961, Puerto Rico
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Shankle Clinic and Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
St. Joseph's Health Care London

London, Ontario, N6C 0A7, Canada
The Centre for Memory and Aging

Toronto, Ontario, Canada
The Clinical Trial Center

Jenkintown, Pennsylvania, 19046, United States
The Cognitive and Research Center of New Jersey (CRCNJ)

Springfield, New Jersey, 07081, United States
The Memory Clinic - Bennington

Bennington, Vermont, 05201, United States
Toronto Memory Program

Toronto, Ontario, M3B 2S7, Canada
True North Clinical Research - Halifax

Halifax, Nova Scotia, B3S 1N2, Canada
True North Clinical Research - New Minas

New Minas, Nova Scotia, B4N 3R7, Canada
USF Health - Byrd Alzheimer's Center and Research Institute

Tampa, Florida, 33613, United States
University of Kentucky Sanders-Brown Center on Aging

Lexington, Kentucky, 40504, United States
Velocity Clinical Research, Formerly Clarity Clinical Research

East Syracuse, New York, 13057, United States

Conditions

Explore the condition pages connected to this study.

ALZHEIMER DISEASE