New Dual-Action antibody enters first human trials for Hard-to-Treat cancers
NCT ID NCT07660432
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new drug called SIM0689 in adults with advanced solid tumors that have stopped responding to standard treatments. SIM0689 is a bispecific antibody designed to block two cancer-promoting pathways (PD1 and VEGF). The trial will first find a safe dose, then expand to see if it shrinks tumors in specific cancer types.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SIM0689 (a bispecific antibody targeting PD1 and VEGF)
What this could lead to
If successful, this could point toward a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
What could go wrong
This is a very early Phase 1 trial, so the drug may not be safe or effective. Side effects are unknown, and only a small number of participants will receive the optimal dose.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Cancer Hospital of Shandong First Medical University
Jinan, Shandong, 250117, China
Contact
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Fujian Cancer Hospital
Fuzhou, Fujian, 350014, China
Contact
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Hunan Cancer Hospital
Changsha, Hunan, 410013, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
Contact
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The First Affiliated Hospital, Zhejiang University school of Medicine
Hangzhou, Zhejiang, 310003, China
Contact
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The First Hospital of China Medical University
Shenyang, Liaoning, 110000, China
Contact