Could a common ED drug ease cystic fibrosis lung inflammation?
NCT ID NCT00659529
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether sildenafil (Revatio), a drug often used for erectile dysfunction, can reduce inflammation in the lungs of people with cystic fibrosis. Thirty-six participants took increasing doses over six weeks. Researchers measured changes in sputum elastase, a marker of inflammation, and other lung health indicators.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sildenafil (Revatio)
- What this could lead to
- If it works, this could point toward a new way to reduce lung inflammation in cystic fibrosis, potentially improving breathing and quality of life.
- What could go wrong
- This is an early-phase trial with only 36 people, so results may not apply widely. Sildenafil can cause side effects like headache, flushing, and low blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Jewish Health
Denver, Colorado, 80206, United States
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