Blood swap trial aims to save lives in High-Risk sickle cell patients
NCT ID NCT04084080
Summary
This study tests whether monthly automated blood exchange transfusions can reduce hospital visits and prevent deaths in adults with sickle cell disease who are at high risk of heart and lung complications. Researchers will compare the transfusion approach against standard care in 173 participants over 12 months. The goal is to see if regularly replacing a patient's red blood cells slows disease progression and improves exercise capacity.
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Contacts and locations
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Locations
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Atrium Health
Charlotte, North Carolina, 28204, United States
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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Duke University
Durham, North Carolina, 27708, United States
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East Carolina University
Greenville, North Carolina, 27834, United States
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Emory University
Atlanta, Georgia, 30322, United States
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Hemorio
Rio de Janeiro, Brazil
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Henri Mondor Hopital
Paris, France
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Howard University Center for Sickle Cell Disease
Washington D.C., District of Columbia, 20060, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Johns Hopkins University
Baltimore, Maryland, 21206, United States
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Kremlin-Bicêtre
Créteil, France
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Montefiore Medical Center
New York, New York, 10461, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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UCSF Benioff Children's Hospital Oakland
Oakland, California, 94609, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of Alabama
Tuscaloosa, Alabama, 35401, United States
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University of Illinois at Chicago
Chicago, Illinois, 60607, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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Virginia Commonwealth University
Richmond, Virginia, 23284, United States
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Washington University-St. Louis
St Louis, Missouri, 63110, United States
Conditions
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