New drug combo aims to shrink breast tumors before surgery

NCT ID NCT07305246

First seen Jan 07, 2026 · Last updated May 07, 2026 · Updated 14 times

Summary

This study tests a new drug called SHR-A1811, given alone or with hormone therapy (letrozole), before surgery for early-stage breast cancer that is hormone-receptor-positive and HER2-low. About 120 women will be randomly assigned to one of three groups: the new drug plus hormone therapy, the new drug alone, or standard chemotherapy. The goal is to see if the new approach works better at eliminating cancer in the breast and lymph nodes at the time of surgery.

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