New drug combo aims to boost surgery success for esophageal cancer
NCT ID NCT07607210
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether adding an experimental immunotherapy drug (SHR-1701) to standard chemotherapy can improve outcomes for people with a specific type of esophageal cancer (Siewert type II) that can be surgically removed. About 38 participants will receive the drug combination before and after surgery. The main goal is to see if the cancer is completely gone at the time of surgery (pathological complete response) and if the tumor can be fully removed (R0 resection).
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SHR-1701 (an experimental immunotherapy drug) combined with chemotherapy (S-1 and oxaliplatin)
What this could lead to
If successful, this could offer a more effective treatment approach for this specific esophageal cancer, potentially increasing the chance of complete tumor removal during surgery.
What could go wrong
This is a small, early-phase trial (38 participants) with no results yet. The drug combination may cause significant side effects, and the benefit over standard treatment is unproven.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••