Gene-Targeted therapy fails to outperform standard care in advanced cancer trial
NCT ID NCT01771458
First seen Jan 10, 2026 · Last updated May 21, 2026 · Updated 16 times
Summary
This study tested whether choosing cancer drugs based on the genetic profile of a patient's tumor could work better than standard chemotherapy. 742 adults with advanced solid tumors that had stopped responding to treatment were randomly assigned to either a targeted therapy matched to their tumor's molecular abnormalities or the doctor's choice of conventional therapy. The main goal was to see if the personalized approach could slow cancer growth longer, but the trial found no significant improvement in progression-free survival.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Centre Alexis Vautrin
Vandœuvre-lès-Nancy, 54500, France
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Centre Leon Berard
Lyon, 69373, France
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Centre régional de lutte contre le cancer de Bourgogne Georges François Leclerc
Dijon, 21079, France
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Insitut Curie
Paris, 75248, France
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Institut Claudius Régaud
Toulouse, 31052, France
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Institut Curie Hopital Rene Huguenin
Saint-Cloud, 92210, France
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Institut Paoli Calmettes
Marseille, 13009, France
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Institut de cancérologie de l'Ouest Centre René Gauducheau
Saint-Herblain, 44000, France
Conditions
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