Blood test could spot colon cancer in second round of screening

NCT ID NCT06880055

Recruiting now Diagnosis Sponsor: Guardant Health, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at how well the Shield blood test finds colorectal cancer and advanced growths in people aged 45 to 81 who are at average risk. About 3,375 participants will take the test and then have a colonoscopy to compare results. The goal is to see if the blood test works well for a second round of screening.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLO-RECTAL CANCER

Contacts and locations

Locations

Alliance Research Institute, LLC
RECRUITING

Canoga Park, California, 91304, United States
Amicis Research Center
RECRUITING

Granada Hills, California, 91344, United States
Amicis Research Center
RECRUITING

Sherman Oaks, California, 91403, United States
Amicis Research Center
RECRUITING

Valencia, California, 91355, United States
Associated Gastroenterologists of Central New York
RECRUITING

Camillus, New York, 13031, United States
Associated Gastroenterologists of Central New York
RECRUITING

Fayetteville, New York, 13066, United States
Cary Gastroenterology Associates
RECRUITING

Cary, North Carolina, 27518, United States
Center for Digestive Disease
RECRUITING

Shenandoah, Texas, 77384, United States
Christie Clinic
RECRUITING

Champaign, Illinois, 61822, United States
Christie Clinic
ACTIVE_NOT_RECRUITING

Champaign, Illinois, 61822, United States
Coral Clinics
RECRUITING

Winnetka, California, 91306, United States
Desert Oasis Healthcare Medical Group
RECRUITING

Palm Springs, California, 92262, United States
Digestive Disease Associates
RECRUITING

Branford, Connecticut, 06405, United States
Digestive Disease Associates
RECRUITING

Branford, Connecticut, 06405, United States
Digestive Disease Consultants
RECRUITING

Bourbonnais, Illinois, 60914, United States
Digestive Disease Consultants
RECRUITING

Bourbonnais, Illinois, 60914, United States
Digestive Health Services
RECRUITING

Downers Grove, Illinois, 60515, United States
Digestive Health Services
RECRUITING

Downers Grove, Illinois, 60515, United States
Elite Primary Physicians, Inc.
RECRUITING

Anaheim, California, 92805, United States
Embassy Research Network
RECRUITING

Bloomfield Township, Michigan, 48302, United States
Florida South Research Phase I-IV, Inc.
RECRUITING

Miami, Florida, 33166, United States
GI Solutions of Illinois
RECRUITING

Chicago, Illinois, 60631, United States
GI Solutions of Illinois
RECRUITING

Chicago, Illinois, 60631, United States
GastroCare LI
RECRUITING

Valley Stream, New York, 11581, United States
GastroCare LI
RECRUITING

Valley Stream, New York, 11581, United States
Gastroenterology Associates of New Jersey
ACTIVE_NOT_RECRUITING

Hackensack, New Jersey, 07601, United States
Gastroenterology Associates of New Jersey
ACTIVE_NOT_RECRUITING

Wayne, New Jersey, 07470, United States
Gastroenterology Associates of New Jersey, LLC
RECRUITING

Clifton, New Jersey, 07013, United States
Gastroenterology Associates of New Jersey, LLC
RECRUITING

Montclair, New Jersey, 07042, United States
Gastroenterology Associates of New Jersey, LLC
RECRUITING

Ridgewood, New Jersey, 07450, United States
Gastroenterology Associates of New Jersey, LLC
RECRUITING

Wayne, New Jersey, 07470, United States
Gastroenterology Consultants of Boca Raton, LLC
RECRUITING

Boca Raton, Florida, 33486, United States
Gastroenterology and Internal Medicine Specialists (GAIMS)
RECRUITING

Lake Barrington, Illinois, 60010, United States
Gastroenterology and Internal Medicine Specialists (GAIMS)
RECRUITING

Lake Barrington, Illinois, 60010, United States
Health Living at Pottstown Medical Specialists, Inc
RECRUITING

Pottstown, Pennsylvania, 19464, United States
Horizon Clinical Research Group
RECRUITING

Tomball, Texas, 77375, United States
Horizon Clinical Research Group
RECRUITING

Tomball, Texas, 77375, United States
Hutchinson Clinic
ACTIVE_NOT_RECRUITING

Hutchinson, Kansas, 67502, United States
Innova Pharma Research, LLC
RECRUITING

Doral, Florida, 33172, United States
Integrity Advanced Therapeutics, PLLC
RECRUITING

Houston, Texas, 77090, United States
Manuel Espinel MD PA
RECRUITING

Delray Beach, Florida, 33484, United States
Marisela Gonzalez, MD
RECRUITING

Miami, Florida, 33134, United States
NMC Research
RECRUITING

Tampa, Florida, 33607, United States
NYU Langone
RECRUITING

New York, New York, 10010, United States
Northlake Gastroenterology Associates
RECRUITING

Covington, Louisiana, 70433, United States
Northlake Gastroenterology Associates
RECRUITING

Hammond, Louisiana, 70403, United States
Northshore Center for Gastroenterology (NCG)
RECRUITING

Libertyville, Illinois, 60048, United States
Orchard Park Family Practice
RECRUITING

Orchard Park, New York, 14127, United States
Paragon Rx Clinical, Inc.
WITHDRAWN

Garden Grove, California, 92840, United States
Physicians Group of South Florida
RECRUITING

North Miami, Florida, 33181, United States
Piedmont Healthcare LLC
ACTIVE_NOT_RECRUITING

Statesville, North Carolina, 28625, United States
Piedmont Healthcare, P.A.
ACTIVE_NOT_RECRUITING

Mocksville, North Carolina, 27028, United States
Pinehurst Medical Clinic
WITHDRAWN

Pinehurst, North Carolina, 28374, United States
Premier Family Physicians
ACTIVE_NOT_RECRUITING

Austin, Texas, 78735, United States
Premier Family Physicians
ACTIVE_NOT_RECRUITING

Austin, Texas, 78746, United States
Quinn Healthcare, PLLC
RECRUITING

Ridgeland, Mississippi, 39157, United States
Research Associates of South Florida, LLC
RECRUITING

Miami, Florida, 33134, United States
Sanford Cardiology Pinehurst Medical Clinic
WITHDRAWN

Sanford, North Carolina, 27330, United States
Southeast Valley Gastroenterology Consultants
RECRUITING

Chandler, Arizona, 85224, United States
Southeast Valley Gastroenterology Consultants
RECRUITING

Gilbert, Arizona, 85297, United States
Southwest Gastroenterology (SWG)
RECRUITING

Oak Lawn, Illinois, 60453, United States
Southwest Gastroenterology (SWG)
RECRUITING

Oak Lawn, Illinois, 60453, United States
Syracuse Gastroenterological Associates, P.C.
RECRUITING

East Syracuse, New York, 13057, United States
Tidewater Physician Multispecialty Group Clinical Research
RECRUITING

Williamsburg, Virginia, 23188, United States
US Digestive Health at Blair
RECRUITING

Altoona, Pennsylvania, 16602, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of North Carolina at Chapel Hill
RECRUITING

Hillsborough, North Carolina, 27278, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.