Experimental drug SGI-110 tested for rare tumors, but study stopped early

NCT ID NCT03165721

First seen Feb 18, 2026 · Last updated May 15, 2026 · Updated 14 times

Summary

This study tested a drug called SGI-110 (guadecitabine) in people aged 12 and older with certain rare cancers that did not respond to other treatments. The cancers included wild-type GIST (a stomach or intestinal tumor), pheochromocytoma/paraganglioma (adrenal or nerve tumors), and a type of kidney cancer linked to HLRCC. The drug was given as a daily injection for 5 days every 28 days. The study was terminated early after enrolling only 9 participants, so results are limited.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

Conditions

Explore the condition pages connected to this study.